Kim N Cajachagua-Torres, Hugo G Quezada-Pinedo, Tong Wu, Leonardo Trasande, Akhgar Ghassabian
{"title":"Exposure to Endocrine Disruptors in Early life and Neuroimaging Findings in Childhood and Adolescence: a Scoping Review.","authors":"Kim N Cajachagua-Torres, Hugo G Quezada-Pinedo, Tong Wu, Leonardo Trasande, Akhgar Ghassabian","doi":"10.1007/s40572-024-00457-4","DOIUrl":null,"url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Evidence suggests neurotoxicity of endocrine disrupting chemicals (EDCs) during sensitive periods of development. We present an overview of pediatric population neuroimaging studies that examined brain influences of EDC exposure during prenatal period and childhood. RECENT FINDINGS: We found 46 studies that used magnetic resonance imaging (MRI) to examine brain influences of EDCs. These studies showed associations of prenatal exposure to phthalates, organophosphate pesticides (OPs), polyaromatic hydrocarbons and persistent organic pollutants with global and regional brain structural alterations. Few studies suggested alteration in functional MRI associated with prenatal OP exposure. However, studies on other groups of EDCs, such as bisphenols, and those that examined childhood exposure were less conclusive. These findings underscore the potential profound and lasting effects of prenatal EDC exposure on brain development, emphasizing the need for better regulation and strategies to reduce exposure and mitigate impacts. More studies are needed to examine the influence of postnatal exposure to EDC on brain imaging.</p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":null,"pages":null},"PeriodicalIF":7.4000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324673/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Environmental Health Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40572-024-00457-4","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
PURPOSE OF REVIEW: Evidence suggests neurotoxicity of endocrine disrupting chemicals (EDCs) during sensitive periods of development. We present an overview of pediatric population neuroimaging studies that examined brain influences of EDC exposure during prenatal period and childhood. RECENT FINDINGS: We found 46 studies that used magnetic resonance imaging (MRI) to examine brain influences of EDCs. These studies showed associations of prenatal exposure to phthalates, organophosphate pesticides (OPs), polyaromatic hydrocarbons and persistent organic pollutants with global and regional brain structural alterations. Few studies suggested alteration in functional MRI associated with prenatal OP exposure. However, studies on other groups of EDCs, such as bisphenols, and those that examined childhood exposure were less conclusive. These findings underscore the potential profound and lasting effects of prenatal EDC exposure on brain development, emphasizing the need for better regulation and strategies to reduce exposure and mitigate impacts. More studies are needed to examine the influence of postnatal exposure to EDC on brain imaging.
综述目的:有证据表明,内分泌干扰化学物(EDCs)会在发育的敏感时期造成神经毒性。我们概述了儿科人群的神经影像学研究,这些研究考察了产前和儿童期接触 EDC 对大脑的影响。最新发现:我们发现有 46 项研究使用磁共振成像 (MRI) 来检测 EDC 对大脑的影响。这些研究表明,产前接触邻苯二甲酸盐、有机磷农药(OPs)、多芳烃和持久性有机污染物与整体和区域性大脑结构改变有关。很少有研究表明功能性核磁共振成像的改变与产前暴露于 OP 有关。然而,对双酚等其他 EDCs 类别的研究以及对儿童期暴露的研究则不太确定。这些研究结果强调了产前 EDC 暴露对大脑发育可能产生的深远而持久的影响,强调需要更好的监管和策略来减少暴露和减轻影响。还需要进行更多的研究来探讨产后接触 EDC 对大脑成像的影响。
期刊介绍:
Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.