Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-07-29 DOI:10.1111/ijpo.13155

Marcos Olvera-Rojas, Abel Plaza-Florido, Patricio Solis-Urra, Francisco J. Osuna-Prieto, Francisco B. Ortega

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引用次数: 0

Abstract

Objective

Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological-related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association with metabolic syndrome markers.

Methods

In this cross-sectional study, we included 84 Caucasian children (39% girls), aged 10.1 ± 1.1 years, from the ActiveBrains project (NCT02295072). A ninety-two-protein targeted approach using Olink's® technology was used.

Results

We identified distinct concentrations of CD38, LAIR2, MANF and NRP2 proteins in MHO compared with MUO. Moreover, individual metabolic syndrome (MS) markers were linked to nine proteins (CD38, CPM, EDA2R, IL12, JAMB, KYNU, LAYN, MSR1 and SMOC2) in children with OW/OB. These proteins play crucial roles in diverse biological processes (e.g., angiogenesis, cholesterol transport, nicotinamide adenine dinucleotide (NAD+) catalysis and maintenance of blood–brain barrier) related to brain health.

Conclusion

Our proteomics study suggests that cardiometabolic health (represented by MHO/MUO or individual MS markers) is associated with the concentration in plasma of several proteins involved in brain health. Larger-scale studies are needed to contrast/confirm these findings, with CD38 standing out as a particularly noteworthy and robust discovery.

Abstract Image

查看原文本刊更多论文

代谢健康和不健康超重/肥胖儿童血浆中与神经相关的蛋白质组图谱。

目的：超重/肥胖（OW/OB）儿童的心脏代谢健康状况较差，但影响大脑健康的机制仍不清楚。我们研究了代谢健康型肥胖（MHO）和代谢不健康型肥胖（MUO）儿童血浆中神经相关循环蛋白的差异以及与代谢综合征标志物的关联：在这项横断面研究中，我们纳入了来自 ActiveBrains 项目（NCT02295072）的 84 名高加索儿童（39% 为女孩），年龄为 10.1 ± 1.1 岁。研究采用了Olink's®技术的92种蛋白靶向方法：结果：与 MUO 相比，我们在 MHO 中发现了不同浓度的 CD38、LAIR2、MANF 和 NRP2 蛋白。此外，在 OW/OB 儿童中，个别代谢综合征（MS）标记物与九种蛋白质（CD38、CPM、EDA2R、IL12、JAMB、KYNU、LAYN、MSR1 和 SMOC2）相关。这些蛋白质在与脑健康有关的各种生物过程（如血管生成、胆固醇转运、烟酰胺腺嘌呤二核苷酸（NAD+）催化和血脑屏障的维护）中发挥着至关重要的作用：我们的蛋白质组学研究表明，心脏代谢健康（以 MHO/MUO 或个别 MS 标志物为代表）与血浆中涉及大脑健康的几种蛋白质的浓度有关。需要进行更大规模的研究来对比/证实这些发现，其中 CD38 是一个特别值得关注的重大发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.