A prospective cohort study on stereotactic radiotherapy in the management of dural recurrence of olfactory neuroblastoma.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-07-29 DOI:10.1002/hed.27887

Christopher D Goodman, Franco DeMonte, Theresa P Nguyen, Adam S Garden, Catherine He Wang, Xin A Wang, Kevin Diao, Anna Lee, Jay Reddy, Amy Moreno, Michael Spiotto, Clifton D Fuller, David Rosenthal, Renata Ferrarotto, Shaan M Raza, Shirley Y Su, Andrew Warner, Ehab Hanna, Jack Phan

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Abstract

Background: Treatment for dural recurrence of olfactory neuroblastoma (ONB) is not standardized. We assess the outcomes of stereotactic body radiotherapy (SBRT) in this population.

Methods: ONB patients with dural recurrences treated between 2013 and 2022 on a prospective registry were included. Tumor control, survival, and patient-reported quality of life were analyzed.

Results: Fourteen patients with 32 dural lesions were evaluated. Time to dural recurrence was 58.3 months. Thirty lesions (94%) were treated with SBRT to a median dose of 27 Gy in three fractions. Two patients (3 of 32 lesions; 9%) developed in-field radiographic progression, five patients (38%) experienced progression in non-contiguous dura. Two-year local control was 85% (95% CI: 51-96%). There were no >grade 3 acute toxicities and 1 case of late grade 3 brain radionecrosis.

Conclusion: In this largest study of SBRT reirradiation for ONB dural recurrence to date, high local control rates with minimal toxicity were attainable.

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立体定向放射治疗治疗硬膜复发嗅神经母细胞瘤的前瞻性队列研究。

背景：嗅神经母细胞瘤（ONB）硬脑膜复发的治疗尚未标准化。我们评估了立体定向体放射治疗（SBRT）在这一人群中的疗效：方法：纳入2013年至2022年间接受前瞻性登记治疗的硬脑膜复发嗅神经母细胞瘤患者。对肿瘤控制情况、生存率和患者报告的生活质量进行分析：对14名患者的32处硬膜病变进行了评估。硬脑膜复发时间为58.3个月。30个病灶（94%）接受了SBRT治疗，中位剂量为27 Gy，分三次进行。两名患者（32个病灶中的3个；9%）出现了场内放射学进展，五名患者（38%）出现了非连续硬脑膜进展。两年的局部控制率为85%（95% CI：51-96%）。无3级以上急性毒性反应，1例晚期3级脑放射性坏死：在这项迄今为止规模最大的SBRT再照射治疗ONB硬脑膜复发的研究中，局部控制率高且毒性小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464