Cortical Thickness Correlates of Go/No-go and Motor Sequencing in Mild Cognitive Impairment and Suspected Alzheimer Disease Dementia.

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES
Cierra M Keith, Katharine E Lindberg, Kirk Wilhelmsen, Rashi I Mehta, Camila Vieira Ligo Teixeira, Mark Miller, Melanie Ward, R Osvaldo Navia, William T McCuddy, Liv Miller, Kirk Bryant, Michelle Coleman, Pierre-François D'Haese, Marc W Haut
{"title":"Cortical Thickness Correlates of Go/No-go and Motor Sequencing in Mild Cognitive Impairment and Suspected Alzheimer Disease Dementia.","authors":"Cierra M Keith, Katharine E Lindberg, Kirk Wilhelmsen, Rashi I Mehta, Camila Vieira Ligo Teixeira, Mark Miller, Melanie Ward, R Osvaldo Navia, William T McCuddy, Liv Miller, Kirk Bryant, Michelle Coleman, Pierre-François D'Haese, Marc W Haut","doi":"10.1097/WNN.0000000000000376","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>While the cognitive hallmark of typical Alzheimer disease (AD) is impaired memory consolidation, increasing evidence suggests that the frontal lobes and associated executive functions are also impacted.</p><p><strong>Objective: </strong>We examined two neurobehavioral executive function tasks and associations with cortical thickness in patients diagnosed with mild cognitive impairment (MCI), suspected AD dementia, and a healthy control group.</p><p><strong>Methods: </strong>First, we compared group performances on a go/no-go (GNG) task and on Luria's Fist-Edge-Palm (FEP) motor sequencing task. We then examined correlations between neurobehavioral task performance and the thickness of frontal cortical regions, AD signature regions, broader unbiased brain regions, and white matter hyperintensities (WMH).</p><p><strong>Results: </strong>Participants with MCI performed worse than healthy controls, but better than participants with suspected AD dementia on both tasks. Both GNG and FEP (to a slightly greater extent) tasks showed diffuse associations with most AD signature regions and multiple additional regions within the temporal, parietal, and occipital cortices. Similarly, both tasks showed significant associations with all other cognitive tasks examined. Of the frontal regions examined, only the middle frontal gyrus and pars opercularis were associated with performance on these tasks. Interactions between the precuneus and transtemporal gyri were most predictive of GNG task performance, while the interaction between superior temporal and lingual gyri was most predictive of FEP task performance.</p><p><strong>Conclusion: </strong>This study replicates difficulties with both GNG and FEP tasks in participants with MCI and AD dementia. Both tasks showed widespread associations with the cortical thickness of various brain structures rather than localizing to frontal regions, consistent with the diffuse nature of AD.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":" ","pages":"144-153"},"PeriodicalIF":1.3000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cognitive and Behavioral Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/WNN.0000000000000376","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: While the cognitive hallmark of typical Alzheimer disease (AD) is impaired memory consolidation, increasing evidence suggests that the frontal lobes and associated executive functions are also impacted.

Objective: We examined two neurobehavioral executive function tasks and associations with cortical thickness in patients diagnosed with mild cognitive impairment (MCI), suspected AD dementia, and a healthy control group.

Methods: First, we compared group performances on a go/no-go (GNG) task and on Luria's Fist-Edge-Palm (FEP) motor sequencing task. We then examined correlations between neurobehavioral task performance and the thickness of frontal cortical regions, AD signature regions, broader unbiased brain regions, and white matter hyperintensities (WMH).

Results: Participants with MCI performed worse than healthy controls, but better than participants with suspected AD dementia on both tasks. Both GNG and FEP (to a slightly greater extent) tasks showed diffuse associations with most AD signature regions and multiple additional regions within the temporal, parietal, and occipital cortices. Similarly, both tasks showed significant associations with all other cognitive tasks examined. Of the frontal regions examined, only the middle frontal gyrus and pars opercularis were associated with performance on these tasks. Interactions between the precuneus and transtemporal gyri were most predictive of GNG task performance, while the interaction between superior temporal and lingual gyri was most predictive of FEP task performance.

Conclusion: This study replicates difficulties with both GNG and FEP tasks in participants with MCI and AD dementia. Both tasks showed widespread associations with the cortical thickness of various brain structures rather than localizing to frontal regions, consistent with the diffuse nature of AD.

轻度认知障碍和疑似阿尔茨海默病痴呆症患者的走/走和运动序列的皮质厚度相关性。
背景:典型阿尔茨海默病(AD)的认知特征是记忆巩固功能受损:虽然典型阿尔茨海默病(AD)的认知特征是记忆巩固受损,但越来越多的证据表明,额叶和相关的执行功能也会受到影响:我们研究了被诊断为轻度认知障碍(MCI)的患者、疑似阿兹海默症痴呆症患者以及健康对照组的两项神经行为执行功能任务及其与皮质厚度的关系:首先,我们比较了各组在 "走/不走"(GNG)任务和卢里亚 "拳锋-手掌"(FEP)运动排序任务上的表现。然后,我们研究了神经行为任务表现与额叶皮质区域厚度、AD特征区域、更广泛的无偏倚脑区和白质高密度(WMH)之间的相关性:MCI患者在两项任务中的表现均不如健康对照组,但优于疑似AD痴呆症患者。GNG和FEP(程度稍高)两项任务均显示出与大多数注意力缺失症特征区域以及颞叶、顶叶和枕叶皮层中的多个其他区域的弥漫性关联。同样,这两项任务与所有其他认知任务也有显著关联。在所研究的额叶区域中,只有额叶中回和厣旁与这些任务的表现相关。楔前回和跨颞回之间的相互作用最能预测 GNG 任务的表现,而颞上回和舌回之间的相互作用最能预测 FEP 任务的表现:本研究重复了 MCI 和 AD 痴呆患者在完成 GNG 和 FEP 任务时遇到的困难。这两项任务都与不同大脑结构的皮质厚度有广泛联系,而不是局限于额叶区域,这与 AD 的弥漫性是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信