Reduction of Psychosis Proneness in a Daycare Hospital Program for Patients with Severe Alcohol Use Disorder.

IF 1.5 4区医学 Q3 PSYCHIATRY

Journal of Dual Diagnosis Pub Date : 2024-07-29 DOI:10.1080/15504263.2024.2378874

Camille Lefebvre-Durel, Alix Morel, Alexandra Dereux, Bruno Etain, Virgile Clergue Duval, Florence Vorspan

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引用次数: 0

Abstract

Objectives: Anxiety and depressive symptoms, as well as cognitive dysfunctions, improve with abstinence in individuals with alcohol use disorders (AUD), but less is known about psychotic features. The objective of this study was to evaluate the psychosis proneness in a sample of individuals with severe AUD and potential changes after alcohol withdrawal.

Method: An observational study was conducted, assessing prospectively Peter's Delusional Inventory scale (PDI); anxiety and depression symptoms by MADRS and cognitive functioning by the MoCA at entry in daycare hospital (D0) and after 30 days (D30). Individuals with schizophrenia, chronic delusional disorder and bipolar disorder were excluded. Wilcoxon tests were used to evaluate the evolution between D0 and D30, and linear regressions were conducted to test the association between delta PDI and the variables that could be potential confounders.

Results: Forty individuals (72% males) with a mean age of 50 ± 9 years old and AUD evolved for 15 ± 11 years were included. After one month, PDI score decreased significantly (p = .001), and several biological and clinical parameters improved significantly with abstinence or consumption reduction: GGT (p = .003), MoCA (p < .001), MADRS (p = .047).

Conclusion: We observed a decrease in delusional thinking along abstinence and/or consumption reduction. To our knowledge, this is the first research to study psychosis proneness evolution in patients with severe AUD. Replications are required in independent samples with larger sample size.

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减少严重酒精使用障碍患者日托医院项目中的精神病倾向。

目的：酒精使用障碍（AUD）患者的焦虑和抑郁症状以及认知功能障碍在戒酒后会有所改善，但对精神病特征的了解较少。本研究旨在评估严重酒精中毒性精神障碍患者样本的精神病倾向以及戒酒后的潜在变化：方法：我们进行了一项观察性研究，前瞻性地评估了彼得妄想量表（PDI）、MADRS焦虑和抑郁症状，以及入院时（D0）和30天后（D30）的MoCA认知功能。精神分裂症、慢性妄想症和双相情感障碍患者除外。采用Wilcoxon检验来评估D0和D30之间的演变情况，并进行线性回归来检验δPDI与可能成为潜在混杂因素的变量之间的关联：共纳入 40 名患者（72% 为男性），平均年龄为 50 ± 9 岁，AUD 演变时间为 15 ± 11 年。一个月后，PDI 评分明显下降（p = .001），一些生物和临床参数也随着戒酒或减少饮酒而明显改善：GGT (p = .003)、MoCA (p < .001)、MADRS (p = .047)：结论：我们观察到妄想随着戒酒和/或减量而减少。据我们所知，这是首次对严重 AUD 患者的精神病倾向演变进行研究。需要在样本量更大的独立样本中进行重复研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dual Diagnosis Multiple-

CiteScore

4.90

自引率

13.60%

发文量

期刊介绍： Journal of Dual Diagnosis is a quarterly, international publication that focuses on the full spectrum of complexities regarding dual diagnosis. The co-occurrence of mental health and substance use disorders, or “dual diagnosis,” is one of the quintessential issues in behavioral health. Why do such high rates of co-occurrence exist? What does it tell us about risk profiles? How do these linked disorders affect people, their families, and the communities in which they live? What are the natural paths to recovery? What specific treatments are most helpful and how can new ones be developed? How can we enhance the implementation of evidence-based practices at clinical, administrative, and policy levels? How can we help clients to learn active recovery skills and adopt needed supports, clinicians to master new interventions, programs to implement effective services, and communities to foster healthy adjustment? The Journal addresses each of these perplexing challenges.