Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2024-07-25 DOI:10.1016/j.npep.2024.102457

Xuying Ding , Yutong Chen , Xiaojun Zhang , Yanming Duan , Guojing Yuan , Chang Liu

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引用次数: 0

Abstract

Neurodegenerative diseases are the main causes of death and morbidity among elderly people worldwide. From the pathological point of view, oxidative stress, neuroinflammation, mitochondrial damage and apoptosis are the causes of neuronal diseases, and play a harmful role in the process of neuronal cell death and neurodegeneration. The most common neurodegenerative diseases are Alzheimer's disease(AD) and Parkinson's disease(PD), and there is no effective treatment. The physiological role of active peptides in the human body is significant. Modern medical research has found that animal and plant peptides, natural peptides in human body, can act on the central nervous system, and their active components can improve learning and memory ability, and play the roles of antioxidation, anti-inflammation, anti-apoptosis and maintaining the structure and function of mitochondria. This review reviews the reports on neurodegenerative diseases such as AD and PD by active peptides from animals and plants and natural peptides from the human body, and summarizes the neuroprotective mechanism of peptides. A theoretical basis for further research and development of active peptides was provided by examining the research and application of peptides, which provided a theoretical basis for further research and development.

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关于阿尔茨海默病和帕金森病中活性肽的保护作用和机制的研究进展。

神经退行性疾病是全球老年人死亡和发病的主要原因。从病理角度看，氧化应激、神经炎症、线粒体损伤和细胞凋亡是神经元疾病的病因，在神经细胞死亡和神经退行性变的过程中起着有害作用。最常见的神经退行性疾病是阿尔茨海默病（AD）和帕金森病（PD），目前尚无有效的治疗方法。活性肽在人体内的生理作用非常重要。现代医学研究发现，动植物肽、人体内的天然肽能作用于中枢神经系统，其活性成分能提高学习和记忆能力，并起到抗氧化、抗炎、抗细胞凋亡和维持线粒体结构和功能的作用。本综述综述了动植物活性肽和人体内天然肽对AD、PD等神经退行性疾病的报道，总结了肽的神经保护机制。通过考察活性肽的研究和应用，为进一步研究和开发活性肽提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.