Childhood exposure to polycyclic aromatic hydrocarbons is associated with emotional and behavioral problems in adolescence: a longitudinal study in China.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI:10.1007/s00420-024-02093-9

Yu Tian, Shudan Liu, Wenyi Wu, Qin Zhang, Zixuan Chen, Jie Luo, Yujie Wang, Zongwei He, Qin Liu

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引用次数: 0

Abstract

Purpose: The aim of this study was to investigate the relationship between childhood polycyclic aromatic hydrocarbon (PAH) exposure and emotional and behavioral problems in adolescence.

Methods: Participants included 998 school-age children aged 7-12 years (514 girls and 484 boys). Metabolite concentrations of four PAHs (1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthalene [2-OHNap], 2-hydroxyfluorine [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]) were measured in urine samples at baseline (Dec 2014-Dec 2015). During adolescence, we measured emotional and behavioral problems in study participants. We used logistic regression models to assess the effects of different levels of PAH metabolite concentrations on emotional and behavioral problems for boys and girls, separately.

Results: Boys exposed to 1-OHPyr and 2-OHFlu had a significantly higher risk of externalizing problems (OR: 2.62, 95% CI: 1.09 ~ 6.29; OR: 2.92, 95% CI: 1.15 ~ 7.42). 2-OHNap exposure faced a higher risk of internalizing problems (OR: 3.85, 95% CI: 1.28 ~ 11.58; OR: 3.63, 95% CI: 1.13 ~ 11.63) and externalizing problems (OR: 4.27, 95% CI: 1.44 ~ 12.70; OR: 4.68, 95% CI: 1.49 ~ 14.73). Moreover, boys exposed to 9-OHPhe exhibited a significant risk of anxiety (OR: 2.84, 95% CI: 1.01 ~ 7.97; OR: 3.00, 95% CI: 1.04 ~ 8.68). Similarly, girls exposed to 9-OHPhe had a significant risk of anxiety (OR: 2.41, 95% CI: 1.25 ~ 4.64).

Conclusion: Childhood PAH exposures are associated with emotional and behavioral problems in adolescence, and boys seem more susceptible than girls.

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童年时期接触多环芳烃与青春期的情绪和行为问题有关：一项在中国进行的纵向研究。

目的：本研究旨在调查儿童时期多环芳烃（PAH）暴露与青春期情绪和行为问题之间的关系：参与者包括 998 名 7-12 岁的学龄儿童（514 名女孩和 484 名男孩）。基线期（2014 年 12 月至 2015 年 12 月）的尿液样本中测量了四种 PAHs（1-羟基芘 [1-OHPyr]、2-羟基萘 [2-OHNap]、2-羟基氟 [2-OHFlu] 和 9-羟基菲 [9-OHPhe]）的代谢物浓度。在青春期，我们测量了研究参与者的情绪和行为问题。我们使用逻辑回归模型分别评估了不同水平的多环芳烃代谢物浓度对男孩和女孩情绪和行为问题的影响：暴露于 1-OHPyr 和 2-OHFlu 的男孩出现外化问题的风险明显更高（OR：2.62，95% CI：1.09 ~ 6.29；OR：2.92，95% CI：1.15 ~ 7.42）。接触 2-OHNap 的男孩出现内化问题（OR：3.85，95% CI：1.28 ~ 11.58；OR：3.63，95% CI：1.13 ~ 11.63）和外化问题（OR：4.27，95% CI：1.44 ~ 12.70；OR：4.68，95% CI：1.49 ~ 14.73）的风险较高。此外，接触 9-OHPhe 的男孩有显著的焦虑风险（OR：2.84，95% CI：1.01 ~ 7.97；OR：3.00，95% CI：1.04 ~ 8.68）。同样，暴露于 9-OHPhe 的女孩也有显著的焦虑风险（OR：2.41，95% CI：1.25 ~ 4.64）：结论：童年时期接触 PAH 与青春期的情绪和行为问题有关，男孩似乎比女孩更容易受到影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.