The Molecular Mechanism of Aurora-B Regulating Kinetochore-Microtubule Attachment in Mitosis and Oocyte Meiosis.

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2024-01-01 Epub Date: 2024-07-27 DOI:10.1159/000540588

Shanshan Chen, Qiqi Sun, Bo Yao, Yanping Ren

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引用次数: 0

Abstract

Background: Aurora kinase B (Aurora-B), a member of the chromosomal passenger complex, is involved in correcting kinetochore-microtubule (KT-MT) attachment errors and regulating sister chromatid condensation and cytoplasmic division during mitosis.

Summary: However, few reviews have discussed its mechanism in oocyte meiosis and the differences between its role in mitosis and meiosis. Therefore, in this review, we summarize the localization, recruitment, activation, and functions of Aurora-B in mitosis and oocyte meiosis. The accurate regulation of Aurora-B is essential for ensuring accurate chromosomal segregation and correct KT-MT attachments. Aurora-B regulates the stability of KT-MT attachments by competing with cyclin-dependent kinase 1 to control the phosphorylation of the SILK and RVSF motifs on kinetochore scaffold 1 and by competing with protein phosphatase 1 to influence the phosphorylation of NDC80 which is the substrate of Aurora-B. In addition, Aurora-B regulates the spindle assembly checkpoint by promoting the recruitment and activation of mitotic arrest deficient 2.

Key messages: This review provides a theoretical foundation for elucidating the mechanism of cell division and understanding oocyte chromosomal aneuploidy.

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Aurora-B 在有丝分裂和卵母细胞减数分裂中调控动点核-微管附着的分子机制

背景：极光激酶B（Aurora-B）是染色体客体复合体（CPC）的成员之一，在有丝分裂过程中参与纠正着丝点-微管（KT-MT）的附着错误并调节姐妹染色单体的凝集和细胞质的分裂。摘要：然而，很少有综述讨论其在卵母细胞减数分裂中的机制及其在有丝分裂和减数分裂中作用的差异。因此，本综述总结了Aurora-B在有丝分裂和卵母细胞减数分裂中的定位、招募、激活和功能。Aurora-B 的准确调控对确保染色体的准确分离和 KT-MT 的正确连接至关重要。Aurora-B 通过与细胞周期蛋白依赖性激酶 1（CDK1）竞争，控制动点支链支架 1 上的 SILK 和 RVSF 矩阵的磷酸化，以及与蛋白磷酸酶 1（PP1）竞争，影响 Aurora-B 底物 NDC80 的磷酸化，从而调节 KT-MT 连接的稳定性。此外，Aurora-B 还通过促进有丝分裂停滞缺陷 2（MAD2）的招募和激活来调节纺锤体组装检查点（SAC）：本综述为阐明细胞分裂机制和理解卵母细胞染色体非整倍体提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.