Evidence further linking the intestine to cardiovascular disease.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in lipidology Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI:10.1097/MOL.0000000000000944

Dawoud Sulaiman, Srinivasa T Reddy, Alan M Fogelman

{"title":"Evidence further linking the intestine to cardiovascular disease.","authors":"Dawoud Sulaiman, Srinivasa T Reddy, Alan M Fogelman","doi":"10.1097/MOL.0000000000000944","DOIUrl":null,"url":null,"abstract":"Purpose of review: To review recent publications linking the intestine to cardiovascular disease.Recent findings: Aromatic amino acid-derived metabolites produced by gut-bacteria were identified that increased or decreased the risk of cardiovascular events. Dietary phenylalanine was metabolized to phenylacetic acid by gut microbes, and converted into phenylacetylglutamine by the host, which increased thrombosis potential via adrenergic receptors and was associated with increased major adverse cardiovascular events. Another microbiota-associated metabolite of aromatic amino acids, indole-3-propionic acid, protected against heart failure with preserved ejection fraction. The mechanism by which dietary cholesterol is absorbed was found to involve the Nieman-Pick C1-like1 protein working together with a newly discovered protein called Aster. Levels of gut-derived bacterial lipopolysaccharide in serum that are an order of magnitude less than those seen in gram negative sepsis were shown to play a role in enhancing atherosclerosis and thrombosis.Summary: Promising new therapeutic targets in the intestine for preventing or treating cardiovascular disease have been identified.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"223-227"},"PeriodicalIF":3.8000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377042/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in lipidology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MOL.0000000000000944","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: To review recent publications linking the intestine to cardiovascular disease.

Recent findings: Aromatic amino acid-derived metabolites produced by gut-bacteria were identified that increased or decreased the risk of cardiovascular events. Dietary phenylalanine was metabolized to phenylacetic acid by gut microbes, and converted into phenylacetylglutamine by the host, which increased thrombosis potential via adrenergic receptors and was associated with increased major adverse cardiovascular events. Another microbiota-associated metabolite of aromatic amino acids, indole-3-propionic acid, protected against heart failure with preserved ejection fraction. The mechanism by which dietary cholesterol is absorbed was found to involve the Nieman-Pick C1-like1 protein working together with a newly discovered protein called Aster. Levels of gut-derived bacterial lipopolysaccharide in serum that are an order of magnitude less than those seen in gram negative sepsis were shown to play a role in enhancing atherosclerosis and thrombosis.

Summary: Promising new therapeutic targets in the intestine for preventing or treating cardiovascular disease have been identified.

查看原文本刊更多论文

有证据进一步证明肠道与心血管疾病有关。

综述目的：综述最近发表的有关肠道与心血管疾病相关的文章：最新发现：肠道细菌产生的芳香族氨基酸代谢物可增加或降低心血管事件的风险。膳食中的苯丙氨酸被肠道微生物代谢为苯乙酸，并被宿主转化为苯乙酰谷氨酰胺，通过肾上腺素能受体增加血栓形成的可能性，并与主要不良心血管事件的增加有关。另一种与微生物相关的芳香族氨基酸代谢产物吲哚-3-丙酸对射血分数保留型心力衰竭有保护作用。研究发现，膳食胆固醇的吸收机制涉及尼曼-皮克 C1-like1 蛋白与一种新发现的名为 Aster 的蛋白质共同作用。肠道细菌脂多糖在血清中的含量比在革兰氏阴性败血症中的含量低一个数量级，这被证明在促进动脉粥样硬化和血栓形成中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.