Immuno-inflammatory and organ dysfunction markers in severe COVID-19 patients

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-07-27 DOI:10.1016/j.cyto.2024.156715

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引用次数: 0

Abstract

Infection with the SARS-CoV-2 virus may induce some complications among people who experience mild to moderate respiratory illness and some of them recover without requiring special treatment. Albeit, some individuals become seriously reached risk points and require special medical attention especially older people and people who suffer from chronic diseases. Serum and whole blood samples were collected from confirmed infected persons with SARS CoV-2 by real-time PCR and the control group. All lab. Investigations were performed using Cobas 6000. Significant differences were noted between patients compared to the control group in the Mean ± SD of IL-6 (76.06 ± 7.60 vs 3.61 ± 0.296 pg/ml), Procalcitonin (0.947 ± 0.117 vs 0.061 ± 0.007 ng/ml), CRP (125.3 ± 7.560 vs 4.027 ± 0.251 mg/dl), ALT (154.8 ± 30.47 vs 49.75 ± 2.977 IU/L) and AST (70.83 ± 9.215 vs 27.23 ± 1.767) respectively. While other parameters were also showed significant differences were noted between patients compared to the control group for D-Dimmer, PT, PTT, LDH, Ferritin, WBC, Lymphocyte and Creatinine. The results reached that the effect of SARS CoV-2 and cytokine storm was clear on the body’s organs through vital biomarker investigations that were performed in this study.

查看原文本刊更多论文

严重 COVID-19 患者的免疫炎症和器官功能障碍指标。

感染 SARS-CoV-2 病毒后，轻度至中度呼吸道疾病患者可能会出现一些并发症，其中一些人无需特殊治疗即可痊愈。尽管如此，有些人会成为严重的风险点，需要特别的医疗护理，尤其是老年人和患有慢性疾病的人。通过实时聚合酶链式反应（real-time PCR）从确诊感染 SARS CoV-2 的患者和对照组中采集血清和全血样本。所有实验室检测均使用 Cobas 6000 进行。与对照组相比，患者的 IL-6（76.06 ± 7.60 vs 3.61 ± 0.296 pg/ml）、降钙素原（0.947 ± 0.117 vs 0.061 ± 0.007 ng/ml）、CRP（125.3 ± 7.560 vs 4.027 ± 0.251 mg/dl）、ALT（154.8 ± 30.47 vs 49.75 ± 2.977 IU/L）和 AST（70.83 ± 9.215 vs 27.23 ± 1.767）。与对照组相比，患者的 D-二聚体、PT、PTT、LDH、铁蛋白、白细胞、淋巴细胞和肌酐等其他指标也存在明显差异。结果表明，通过本研究中进行的重要生物标志物调查，SARS CoV-2 和细胞因子风暴对人体器官的影响是显而易见的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.