An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2024-07-27 DOI:10.1007/s11030-024-10858-0

Anirudh Pratap Singh Raman, Mohd. Aslam, Amardeep Awasthi, Anas Ansari, Pallavi Jain, Kashmiri Lal, Indra Bahadur, Prashant Singh, Kamlesh Kumari

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Abstract

The synthesis of triazoles has attracted a lot of interest in the field of organic chemistry because of its versatile chemical characteristics and possible biological uses. This review offers an extensive overview of the different pathways used in the production of triazoles. A detailed analysis of recent research indicates that triazole compounds have a potential range of pharmacological activities, including the ability to inhibit enzymes, and have antibacterial, anticancer, and antifungal activities. The integration of computational and experimental methods provides a thorough understanding of the structure–activity connection, promoting sensible drug design and optimization. By including triazoles as essential components in drug discovery, researchers can further explore and innovate in the synthesis, biological assessment, and computational studies of triazoles as drugs, exploring the potential therapeutic significance of triazoles.

Graphical abstract

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1,2,3-/1,2,4-三唑的最新综述：合成与多种生物潜力

三唑因其多变的化学特性和可能的生物用途，在有机化学领域引起了广泛的兴趣。本综述广泛概述了生产三唑的不同途径。对最新研究的详细分析表明，三唑化合物具有一系列潜在的药理活性，包括抑制酶的能力，以及抗菌、抗癌和抗真菌活性。计算和实验方法的结合使人们对结构与活性之间的联系有了透彻的了解，从而促进了合理的药物设计和优化。将三唑作为药物发现的重要组成部分，研究人员可以在三唑类药物的合成、生物学评估和计算研究方面进一步探索和创新，探索三唑类药物的潜在治疗意义。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;