Core–Shell Plasmonic Nanostructures for Hyperthermia of Cancer and Tumor Cells

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2024-07-27 DOI:10.1007/s11468-024-02435-w

Vahid Rajabpour, Karim Abbasian, Mehmet Ertugrul

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Abstract

Plasmonic nanostructures continue to be the most promising alternative to hyperthermia treatment of cancer or tumors by focusing the light locally. Absorption and scattering cross-sections of 48 nanorods encompassing silver and palladium as core and gold and platinum as coating with four different aspect ratios and three different coating thicknesses were examined in an aqueous solution with finite-element method (FEM). According to the highest value of photothermal conversion efficiency (PCE) in each bimetallic compound, three Au@Ag, Pt@Ag, and Au@Pd nanorods, with aspect ratios of 4, 4, and 5, respectively; and all with a coating thickness of 1 nm; were chosen as the best ones named “A,” “B,” and “C”. Each nanorod irradiated by continuous wave (CW) laser radiation with 1 mW·μm⁻² intensity at the LSPR wavelength for 200 ns, the temperature of the nanorods increased from 37 to 82.6, 46.34, and 44.33 °C, respectively. To robustly control the temperature in time and locally, the irradiation intensity of the “A” was decreased to 0.5 mW·μm⁻², that its ambient temperature increased by 45 °C at a distance of 20 nm, which can selectively cause irreparable damage to the cancer cells. In addition, the nanorods were irradiated by pulsed laser for 200 ns periods. The results show that the bimetallic nanoparticles can convert light into heat locally.

Graphical Abstract

Abstract Image

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用于癌症和肿瘤细胞热疗的核壳质子纳米结构

质子纳米结构通过在局部聚焦光线，仍然是癌症或肿瘤热疗最有前途的替代方法。利用有限元法（FEM）研究了水溶液中以银和钯为核心、金和铂为涂层的 48 个纳米棒的吸收和散射截面，这些纳米棒具有四种不同的长宽比和三种不同的涂层厚度。根据每种双金属化合物中光热转换效率（PCE）的最高值，选择了三个金@银、铂@银和金@钯纳米棒，它们的长宽比分别为 4、4 和 5，涂层厚度均为 1 nm，并被命名为 "A"、"B "和 "C"。每个纳米棒在 LSPR 波长处接受强度为 1 mW-μm-2 的连续波（CW）激光照射 200 毫微秒后，温度分别从 37 ℃ 升高到 82.6 ℃、46.34 ℃ 和 44.33 ℃。为了在时间上和局部上稳健地控制温度，将 "A "的辐照强度降至 0.5 mW-μm-2，在 20 nm 的距离上，其环境温度升高了 45 ℃，这可以选择性地对癌细胞造成不可修复的损伤。此外，还对纳米棒进行了 200 ns 周期的脉冲激光照射。结果表明，双金属纳米粒子可以在局部将光转化为热。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.

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