One-Pot Synthesis of Pyrido[2,3-d]pyrimidines and 1,2,4-Triazolo[4,3−a]pyrimidines Using a Tropine-Based Dicationic Molten Salt as an Active Catalyst

Abstract

In this research, an environmentally friendly, effective method is documented for the synthesis of pyrido[2,3-d]pyrimidine and 1,2,4-triazolo[4,3-a]pyrimidine derivatives using an affordable and facile-prepared dicationic molten salt based on Tropine. The aforementioned pyrimidine derivatives have found remarkable pharmacological and therapeutic roles. under the influence of this catalyst formulated as [(Tropine)₂C₃H₅OH].2Cl, the products are obtained during 50 to 120 and 15 to 70 min for both reactions respectively, along with high yields from 90 to 98% which was measured through chromatography method, under solvent-free conditions or in EtOH as a green solvent. Also, the catalyst can be easily recovered and reused at least for three times.