Synergistic Gold Nanorod-based Chemo-Photothermal Therapy: A Promising Nanoparticle Approach for Refractory Multidrug-Resistant Cancer

IF 6.2 3区工程技术 Q1 ENGINEERING, CHEMICAL

ChemBioEng Reviews Pub Date : 2024-07-25 DOI:10.1002/cben.202300046

Haifa A. Alqahtani, Dalal Mohamed Alshangiti, Nadiah Aldaleeli, Mohamed Madani, Samera Ali Al-Gahtany, Mohamed Mohamady Ghobashy

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Abstract

Multidrug resistance (MDR) remains a formidable challenge in cancer treatment, necessitating innovative strategies to enhance therapeutic outcomes. This review explores the potential of a synergistic gold nanorod (GNR) therapy (SGNRT) utilizing GNRs as multifunctional platforms for co-delivering chemotherapy and thermal therapies. The rational design of SGNRT systems enables targeted payload delivery, circumvention of Adenosine triphosphate (ATP)-binding cassette drug efflux transporters, and hyperthermia-induced chemo sensitization. In vitro studies demonstrate the synergistic impact of SGNRT in overcoming MDR, emphasizing its potential for enhanced antitumor efficacy. However, further in vivo investigations are essential to assess the clinical viability of this nanoparticle (NP)-directed approach against advanced multidrug-resistant malignancies. The integration of SGNRT holds promise for advancing precision cancer therapies and addressing the intricate challenges of drug resistance in clinical settings.

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基于金纳米棒的化疗-热疗协同疗法：治疗难治性多药耐药性癌症的前景广阔的纳米粒子疗法

多药耐药性（MDR）仍然是癌症治疗中的一个巨大挑战，因此有必要采取创新策略来提高治疗效果。这篇综述探讨了金纳米棒（GNR）协同疗法（SGNRT）的潜力，该疗法利用 GNRs 作为多功能平台，共同传递化疗和热疗药物。SGNRT 系统的合理设计可实现有针对性的有效载荷递送、规避三磷酸腺苷（ATP）结合盒药物外排转运体以及热疗诱导的化疗增敏。体外研究证明了 SGNRT 在克服 MDR 方面的协同作用，强调了其增强抗肿瘤疗效的潜力。然而，要评估这种以纳米粒子（NP）为导向的方法对晚期耐多药恶性肿瘤的临床可行性，还需要进一步的体内研究。SGNRT 的整合有望推动癌症精准疗法的发展，并解决临床环境中耐药性带来的复杂挑战。

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来源期刊

ChemBioEng Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.90

自引率

2.10%

发文量

期刊介绍： Launched in 2014, ChemBioEng Reviews is aimed to become a top-ranking journal publishing review articles offering information on significant developments and provide fundamental knowledge of important topics in the fields of chemical engineering and biotechnology. The journal supports academics and researchers in need for concise, easy to access information on specific topics. The articles cover all fields of (bio-) chemical engineering and technology, e.g.,