3,6-Disubstituted derivatives of 1,2,4,5-tetrazine with pyridinyl amidine moieties and condensed systems on their basis: synthesis, docking, and antibacterial activity

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-07-26 DOI:10.1007/s11172-024-4286-7

R. I. Ishmetova, N. K. Ignatenko, N. A. Gerasimova, D. V. Belyaev, I. I. Butorin, O. A. Konovalova, E. E. Khramtsova, D. V. Dianov, N. P. Evstigneeva, D. V. Vakhrusheva, S. Yu. Krasnoborova, N. V. Zilberberg, N. V. Kungurov, G. L. Rusinov, V. N. Charushin

引用次数: 0

Abstract

New 3,6-disubstituted 1,2,4,5-tetrazine derivatives with pyridyl-substituted amidine moieties, as well as [1,2,4]triazolo[1,5-b][1,2,4,5-tetrazines and bis[1,2,4]triazolo-[1,5-b:1,5-f][1,2,4,5]tetrazines on their basis were synthesized. The obtained compounds were screened for activity against Neisseria gonorrhoeae and Mycobacterium tuberculosis. Compounds with pronounced antibacterial activity were detected. Docking was performed to determine a possible antibacterial effect of the compounds.

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具有吡啶基脒分子的 1,2,4,5-四嗪的 3,6-二取代衍生物及其缩合体系：合成、对接和抗菌活性

在其基础上合成了具有吡啶基取代的脒基的新的 3,6 二甲基 1,2,4,5 四嗪衍生物，以及 [1,2,4]triazolo[1,5-b][1,2,4,5-tetrazines 和双[1,2,4]triazolo-[1,5-b:1,5-f][1,2,4,5]tetrazines。对获得的化合物进行了筛选，以检测其对淋病奈瑟菌和结核分枝杆菌的活性。结果发现，这些化合物具有明显的抗菌活性。为了确定这些化合物可能具有的抗菌效果，对它们进行了对接。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.