Innovative Self Nano‐Emulsifying Drug Delivery Systems for Peptic Ulcer Therapy: A Review

IF 2.7 4区材料科学 Q3 CHEMISTRY, PHYSICAL

Particle & Particle Systems Characterization Pub Date : 2024-07-26 DOI:10.1002/ppsc.202400070

Syed Hassan Mujtaba, Rabia Arshad, Waqar Aman, Kashif Barkat, Abdul Malik, Anam Fatima, Salman Arshad Khan, Haleema Sadia, Gul e Maryam, Zeinab Moafian, Abbas Rahdar, M. Ali Aboudzadeh

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引用次数: 0

Abstract

Peptic ulcer disease (PUD) adversely affects ≈4 million individuals globally and remains pervasive among 5–10% of the general population. Mucosal lesions prompted by the ulceration lead to the penetration through mucosal layers, ultimately resulting in cavity formation and inflammation. Conventional therapeutic modalities for peptic ulcers have shown unfavorable effects, relapses, and numerous drug interactions. The genesis of gastric ulcers is catalyzed via an imbalanced interplay between environmental lesions, defensive mechanisms, and the restoration of gastric mucosa. Lipid based nanotechnology involved in self‐nanoemulsifying drug delivery system (SNEDDS) is being tremendously involved in opening avenues in innovative pharmaceutical delivery systems in terms of improving solubility and regenerative healing against peptic ulcers. Biological macromolecules can be incorporated into SNEDDS to embellish the drug delivery system on an advanced level. Herein, in this review, the potential of SNEDDS as a viable carrier for administering biomacromolecules for regenerative healing in ulcers is discussed in detail.

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用于消化性溃疡治疗的创新型自纳米乳化给药系统：综述

消化性溃疡病（PUD）对全球 400 万人造成了不利影响，在 5-10% 的普通人群中仍普遍存在。溃疡引起的粘膜病变会穿透粘膜层，最终导致空腔形成和炎症。消化性溃疡的传统治疗方法效果不佳，容易复发，而且药物之间存在许多相互作用。胃溃疡的形成是由环境病变、防御机制和胃黏膜修复之间的不平衡相互作用催化的。自纳米乳化给药系统（SNEDDS）所采用的脂质纳米技术在改善溶解度和消化性溃疡的再生愈合方面为创新给药系统开辟了广阔的前景。生物大分子可融入 SNEDDS，使给药系统更上一层楼。在这篇综述中，我们将详细讨论 SNEDDS 作为一种可行的载体，在溃疡再生愈合中施用生物大分子的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Particle & Particle Systems Characterization 工程技术-材料科学：表征与测试

CiteScore

5.50

自引率

0.00%

发文量

114

审稿时长

3.0 months

期刊介绍： Particle & Particle Systems Characterization is an international, peer-reviewed, interdisciplinary journal focusing on all aspects of particle research. The journal joined the Advanced Materials family of journals in 2013. Particle has an impact factor of 4.194 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)). Topics covered include the synthesis, characterization, and application of particles in a variety of systems and devices. Particle covers nanotubes, fullerenes, micelles and alloy clusters, organic and inorganic materials, polymers, quantum dots, 2D materials, proteins, and other molecular biological systems. Particle Systems include those in biomedicine, catalysis, energy-storage materials, environmental science, micro/nano-electromechanical systems, micro/nano-fluidics, molecular electronics, photonics, sensing, and others. Characterization methods include microscopy, spectroscopy, electrochemical, diffraction, magnetic, and scattering techniques.