Base‐Catalyzed Decarboxylative Amination of In‐Situ Generated Ortho‐Quinone Methides: Synthesis of Benzyl Amines

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI:10.1002/ajoc.202400380

Dr. Sushree Ranjan Sahoo , Parbat Subba , Prof. Vinod K. Singh

引用次数: 0

Abstract

In this paper, a direct access to benzylic amines from in‐situ generated ortho‐quinone methides (o‐QMs) and isocyanate/isothiocyanate via decarboxylation is described. This base‐catalyzed methodology has high functional group tolerance and shows a wide range of substrate scopes, where H₂O as a nucleophile for isocyanate/isothiocyanate for product formation. The products are insensitive to air and moisture, which makes this synthetic strategy more efficient for the construction of various benzyl amine derivatives.

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原位生成的原位醌甲酰胺的碱催化脱羧胺化反应：苄胺的合成

本文介绍了通过脱羧反应从原位生成的邻醌甲酰胺（o-QMs）和异氰酸酯/异硫氰酸酯直接获得苄胺的方法。这种碱催化的方法对官能团的耐受性很高，并显示出广泛的底物范围，其中 H2O 是异氰酸酯/异硫氰酸酯形成产物的亲核体。产物对空气和湿气不敏感，这使得这种合成策略在构建各种苄胺衍生物时更加高效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.