Primary immune‐mediated neutropenia and precursor‐targeted immune‐mediated anaemia in a 4‐year‐old cat

IF 0.3 Q4 VETERINARY SCIENCES

Veterinary Record Case Reports Pub Date : 2024-07-22 DOI:10.1002/vrc2.957

Victoria Travail, Andrea Di Bella

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引用次数: 0

Abstract

A 4‐year‐old, female, neutered, domestic shorthair was presented for acute onset of lethargy. The cat had been diagnosed with and treated for precursor‐targeted immune‐mediated anaemia 2 years before presentation. The clinical examination was unremarkable. Haematology and biochemistry revealed neutropenia and hyperglobulinaemia. Electrophoresis revealed polyclonal gammopathy. Toxoplasma spp. IgG/IgM, Bartonella spp., feline immunodeficiency virus and feline leukaemia virus serology were negative. Urine culture was negative. A computed tomography scan of the thorax and abdomen revealed an enlarged spleen, and cytology was suggestive of reactive lymphoid hyperplasia. Bone marrow aspirates and biopsies were supportive of primary immune‐mediated neutropenia and recurrence of precursor‐targeted immune‐mediated anaemia. The cat was treated successfully with prednisolone and cyclosporine. The necessity to perform a bone marrow biopsy should be highlighted in this case, as the diagnosis of precursor‐targeted immune‐mediated anaemia and immune‐mediated neutropenia was based on bone marrow sampling, exclusion of infectious disorders and response to immunosuppressive medications.

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一只 4 岁猫的原发性免疫介导的中性粒细胞减少症和前体免疫介导的贫血症

一只 4 岁的雌性阉割短毛猫因急性嗜睡症就诊。发病前两年，该猫曾被诊断为前体靶向免疫性贫血，并接受过治疗。临床检查无异常。血液学和生物化学检查发现它患有中性粒细胞减少症和高球蛋白血症。电泳显示存在多克隆抗体。弓形虫属 IgG/IgM、巴顿氏菌属、猫免疫缺陷病毒和猫白血病病毒血清学检测均为阴性。尿液培养呈阴性。胸部和腹部的计算机断层扫描显示脾脏肿大，细胞学检查提示反应性淋巴细胞增生。骨髓穿刺和活检结果支持原发性免疫介导的中性粒细胞减少症和前体靶向免疫介导的贫血复发。该猫成功接受了泼尼松龙和环孢素治疗。在这个病例中，骨髓活检的必要性应该得到强调，因为前体靶向免疫性贫血和免疫介导的中性粒细胞减少症的诊断是基于骨髓取样、排除感染性疾病和对免疫抑制药物的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Record Case Reports Veterinary-Veterinary (all)

CiteScore

0.50

自引率

33.30%

发文量

266

期刊介绍： Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.