Jinzhi Liu, Huijing Cheng, Xiangnan Yuan, Lu Wang, Jing Gao
{"title":"Amphipathic medical composite cotton gauze with unidirectional drainage and anti-adhesion properties for wound healing","authors":"Jinzhi Liu, Huijing Cheng, Xiangnan Yuan, Lu Wang, Jing Gao","doi":"10.1007/s10570-024-06063-9","DOIUrl":null,"url":null,"abstract":"<p>Medical gauze is the most commonly used dressing in wound treatment. However, the issues of wound margin infiltrated with exudate and tissue adhesion pose severe challenges to the application of gauze. Therefore, studying medical gauze with unidirectional drainage function and anti-adhesion ability is imperative. In this study, nano silica (SiO<sub>2</sub>) sol was used as a modifier to modify the surface of cotton gauze, and hexadecyltrimethoxysilane (HDTMS) was used for low-surface-energy modification to improve the hydrophobicity of gauze. Based on the Janus wettability theory, a multifunctional amphipathic medical composite gauze was prepared by combining hydrophobic cotton gauze with hydrophilic cotton gauze to promote wound healing. The top hydrophilic cotton gauze functioned as an absorption layer, which could directionally transfer the wound exudate away from the wound site, thereby providing a drier condition to reduce the risk of wound infection. The hydrophobically modified cotton gauze in contact with the wound site had an excellent anti-adhesion effect on proteins in exudate to prevent secondary damage caused by dressing change. In addition, we also studied the influence of the surface modification method, contact layer structure, and absorption layer structure on the properties of the gauze, and evaluated the biocompatibility and comfort of the optimized composite gauze, providing an experimental basis for the market promotion and application of functional medical cotton gauze. This study showed that in-situ growth after surface incorporation of SiO<sub>2</sub> particles was the ideal modification method for cotton gauze. The optimized composite gauze had excellent unidirectional drainage function (the unidirectional transmission index difference was above 1400) and anti-adhesion effect (the peel energy was 68.30% lower than that of the control group), no cytotoxicity, and good comfort.</p>","PeriodicalId":511,"journal":{"name":"Cellulose","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellulose","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s10570-024-06063-9","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, PAPER & WOOD","Score":null,"Total":0}
引用次数: 0
Abstract
Medical gauze is the most commonly used dressing in wound treatment. However, the issues of wound margin infiltrated with exudate and tissue adhesion pose severe challenges to the application of gauze. Therefore, studying medical gauze with unidirectional drainage function and anti-adhesion ability is imperative. In this study, nano silica (SiO2) sol was used as a modifier to modify the surface of cotton gauze, and hexadecyltrimethoxysilane (HDTMS) was used for low-surface-energy modification to improve the hydrophobicity of gauze. Based on the Janus wettability theory, a multifunctional amphipathic medical composite gauze was prepared by combining hydrophobic cotton gauze with hydrophilic cotton gauze to promote wound healing. The top hydrophilic cotton gauze functioned as an absorption layer, which could directionally transfer the wound exudate away from the wound site, thereby providing a drier condition to reduce the risk of wound infection. The hydrophobically modified cotton gauze in contact with the wound site had an excellent anti-adhesion effect on proteins in exudate to prevent secondary damage caused by dressing change. In addition, we also studied the influence of the surface modification method, contact layer structure, and absorption layer structure on the properties of the gauze, and evaluated the biocompatibility and comfort of the optimized composite gauze, providing an experimental basis for the market promotion and application of functional medical cotton gauze. This study showed that in-situ growth after surface incorporation of SiO2 particles was the ideal modification method for cotton gauze. The optimized composite gauze had excellent unidirectional drainage function (the unidirectional transmission index difference was above 1400) and anti-adhesion effect (the peel energy was 68.30% lower than that of the control group), no cytotoxicity, and good comfort.
期刊介绍:
Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.