An Assessment of Cryopreserved Semen and Testicular Tissue Collected Before and After Cancer Treatment Initiation

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Management and Research Pub Date : 2024-07-24 DOI:10.2147/cmar.s460960

Marta Julia Fernández-González, Anne-Catherine Radauer-Plank, Anja Borgmann-Staudt, Waldemar Geiger, Irena Goranova, Stephanie Klco-Brosius, Bernhard Ralla, Cornelia Stelzer, Ina Wilkemeyer, Magdalena Balcerek

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Abstract

Purpose: This retrospective cohort study assessed semen and testicular tissue quality from adult and adolescent cancer patients who had samples cryopreserved in the Cryobank of Charité-Universitätsmedizin before and/or after cancer treatment.
Methods and Materials: Medical and cryopreservation data for all samples stored between 03/2004 and 05/2019 were collected retrospectively.
Results: We included information on 601 samples cryopreserved from 506 cancer patients for whom oncologic treatment data were available. The majority of the samples were cryopreserved prior to cancer treatment (460/600, 77%, median 5 days before treatment). Semen quality had a predisposed reduction in those collected from adolescents with testicular and/or hematological malignancies. Analyses of the 140 (23%) samples cryopreserved after treatment initiation (median of 84 days) revealed decreased median concentration and motility following high gonadotoxic-risk treatment. Rate of oligoasthenozoospermia was comparable in samples collected prior to treatment with those provided during follow-up spermiograms within 1 year after treatment initiation (45.5% vs 45.5%). However, an increase was seen in samples collected 1– 2 (9.1% to 90.9%) and 2– 3 (50.0% to 100.0%) years after treatment initiation.
Conclusion: Cancer diagnosis and treatment may impair spermatogenesis; therefore, patient counseling prior to cancer treatment by an oncologist and/or fertility specialist is crucial.

Keywords: cancer, fertility preservation, adolescent, men

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对癌症治疗开始前后采集的冷冻精液和睾丸组织进行评估

目的：这项回顾性队列研究评估了在癌症治疗前和/或治疗后将样本冷冻保存在Charité-Universitätsmedizin冷冻库的成年和青少年癌症患者的精液和睾丸组织质量：回顾性收集了 2004 年 3 月至 2019 年 5 月期间储存的所有样本的医学和冷冻保存数据：结果：我们纳入了从 506 名癌症患者冷冻保存的 601 份样本的信息，这些患者均有肿瘤治疗数据。大多数样本是在癌症治疗前冷冻保存的（460/600，77%，中位数为治疗前 5 天）。从患有睾丸和/或血液恶性肿瘤的青少年中采集的精液样本，其质量容易下降。对开始治疗后（中位数为 84 天）冷冻保存的 140 份样本（23%）进行分析后发现，高性腺毒性风险治疗后，样本的中位数浓度和运动能力均有所下降。在治疗前采集的样本中，少精症发生率与治疗开始后一年内随访精子图中提供的样本相当（45.5% vs 45.5%）。然而，在开始治疗后1-2年（9.1%至90.9%）和2-3年（50.0%至100.0%）采集的样本中，无精子症的比例有所上升：癌症的诊断和治疗可能会影响精子的生成；因此，在癌症治疗前由肿瘤专家和/或生育专家对患者进行咨询至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.