Excessive Daytime Napping Increases the Risk of Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and a Mendelian Randomization Study

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-07-24 DOI:10.2147/nss.s468444

Xiuqi Qiao, Xiaoxia Wang, Lixin Guo, Qi Pan

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Abstract

Background: Prior research based on observations has furnished evidence that supports a connection between daytime napping and the prevalence of non-alcoholic fatty liver disease (NAFLD). Nevertheless, the question of whether this correlation is indicative of a causal link has not been definitively answered.
Methods: We used meta-analysis and Mendelian randomization (MR) to synthesize genetic and observational data. A two-sample MR analysis was conducted, leveraging 105 single-nucleotide polymorphisms (SNPs) known to be associated with daytime napping patterns. Additionally, summary-level data pertaining to NAFLD outcomes were acquired from the comprehensive UK Biobank study. Network meta-analyses were employed to investigate the relationship between excessive daytime napping and NAFLD, while subgroup was also performed.
Results: Significant associations were observed between daytime napping and NAFLD. The systematic review/meta-analysis uncovered a heightened risk of NAFLD development among individuals who engaged in daytime naps exceeding 30 minutes, when compared to those who did not nap(odds ratio [OR] = 1.32, 95% confidence interval [CI]: 1.05 to 1.66). Furthermore, MR analysis indicated that a genetic propensity towards longer daytime napping was significantly linked to an increased likelihood of NAFLD (OR = 2.26, 95% CI: 1.38 to 3.73).
Conclusion: Daytime napping has been found to be causally related to a higher risk of NAFLD. Furthermore, across all participants, napping for an average duration over 30 minutes was linked to an elevated likelihood of NAFLD.

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白天过度午睡会增加罹患非酒精性脂肪肝的风险：一项元分析和一项孟德尔随机研究

背景：先前的观察研究提供的证据表明，白天小睡与非酒精性脂肪肝（NAFLD）的发病率之间存在联系。然而，这种相关性是否表明两者之间存在因果关系，这个问题还没有明确答案：我们采用荟萃分析和孟德尔随机化（MR）方法综合了遗传和观察数据。我们利用已知与白天小睡模式有关的 105 个单核苷酸多态性（SNPs）进行了双样本 MR 分析。此外，还从英国生物库综合研究中获得了与非酒精性脂肪肝结果相关的汇总数据。研究人员采用了网络荟萃分析来研究白天过度午睡与非酒精性脂肪肝之间的关系，同时还进行了分组分析：结果：白天小睡与非酒精性脂肪肝之间存在显著关联。系统回顾/元分析发现，与不午睡的人相比，白天午睡超过 30 分钟的人患非酒精性脂肪肝的风险更高（比值比 [OR] = 1.32，95% 置信区间 [CI]：1.05 至 1.66）。此外，磁共振分析表明，日间小睡时间较长的遗传倾向与非酒精性脂肪肝患病可能性的增加有显著联系（OR = 2.26，95% 置信区间：1.38 至 3.73）：结论：研究发现，白天小睡与非酒精性脂肪肝的高风险有因果关系。此外，在所有参与者中，午睡平均持续时间超过30分钟与非酒精性脂肪肝的患病几率升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.

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