Design and Development of Surface Plasmon Resonance Biosensor for Early Detection of Cervical Cancer Utilizing Nucleus and Cytoplasm

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2024-07-27 DOI:10.1007/s11468-024-02441-y

Trupti Kamani, Shobhit K. Patel, N. K. Anushkannan, Sana ben Khalifa, Saleh Chebaane, Taoufik Saidani

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引用次数: 0

Abstract

Cervical cancer is a significant risk to women’s lives, and early detection is crucial to secure patient quality of life. Currently, doctors’ diagnosis relies on their subjective assessments, as there is no standardized measuring method. The problem can be solved with the optical biosensor as it provides precise and quick consequences in the determination of cancerous cells. This manuscript presents a novel double c-shaped copper-based refractivity biosensor (DCSCRIB) for the recognition of cervical nucleus as well as cervical cytoplasm cells. The double c-shaped copper-based resonator provides high spatial resolution, upper sensitivity, and upper-quality factor making them for novel choice to detect the nucleus and cytoplasm of cervical cancer. The upper sensitivity (S) has been spotted at 1600 nm/RIU for the cervical nucleus with the upper-quality factor (QF) being 1618.37 for the cervical cytoplasm. The upper rate of the figure of merit (FOM) is 1107.18, the detection area (DR) rate is 1925.17, the signal noise ratio (SNR) rate is 33.2155, and the sensor resolution (SR) rate is 0.93 which has been spotted of cervical cytoplasm. The upper detection limit of 0.0004 has been achieved for the natural cytoplasm. This propounded sensor can highly intellect the cervical cancer biomarkers.

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利用细胞核和细胞质设计和开发用于早期检测宫颈癌的表面等离子体共振生物传感器

宫颈癌对妇女的生命构成重大威胁，早期发现对确保患者的生活质量至关重要。目前，由于没有标准化的测量方法，医生的诊断主要依靠主观评估。光学生物传感器可以解决这个问题，因为它能精确、快速地确定癌细胞的位置。本手稿介绍了一种新型双 C 形铜基折射率生物传感器（DCSCRIB），用于识别宫颈细胞核和宫颈细胞质。双 c 型铜基谐振器具有高空间分辨率、高灵敏度和高品质因数，是检测宫颈癌细胞核和细胞质的新选择。宫颈癌细胞核的最高灵敏度（S）为 1600 nm/RIU，宫颈癌细胞质的最高品质因数（QF）为 1618.37。宫颈细胞质的优点系数 (FOM) 上限为 1107.18，检测面积 (DR) 上限为 1925.17，信号噪声比 (SNR) 上限为 33.2155，传感器分辨率 (SR) 上限为 0.93。自然细胞质的检测上限为 0.0004。该传感器能高度识别宫颈癌生物标记物。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.

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