{"title":"Single active Au1O5 clusters for metabolism-inspired sepsis management through immune regulation","authors":"","doi":"10.1016/j.nantod.2024.102416","DOIUrl":null,"url":null,"abstract":"<div><p>Artificial enzymes with reprogrammed and augmented catalytic activities hold significant potential in biomedicine. However, common issues with biocatalysts are the presence of numerous inactive site atoms, leading to inefficiencies in their catalytic processes. To leverage the full potential of active catalytic sites, we aim to minimize the biocatalyst structure, transitioning from nanoparticles or polymetallic atomic clusters down to singular-active-unit molecules. In this context, we have developed a unique single active-site cluster molecule, Au<sub>1</sub>-O<sub>5</sub>-Na<sub>9</sub>-(OH)<sub>4</sub> (AuO) clusters, comprising a single gold atom, five oxygen atoms, and a protective layer, where Au-O acts as a singular-active site displaying elevated catalytic activities without inefficiencies associated with biocatalytic reactions. AuO clusters demonstrate activities reminiscent of nicotinamide adenine dinucleotide oxidase (NOX), glutathione peroxidase (GPx), and urease, among other oxidoreductase functions, through optimal utilization of atoms. Clusters are instrumental in enhancing the redox balance, mitigating inflammation, and averting inflammation-induced cellular apoptosis, thereby preserving immune balance in sepsis. These mechanisms are crucial in sepsis pathogenesis. Demonstrating GPx-like and NOX-like capabilities, the AuO clusters have shown remarkable effectiveness against lipopolysaccharide-induced and cecum ligation puncture-induced multiorgan damage, underscoring their substantial promise for sepsis management.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S174801322400272X","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Artificial enzymes with reprogrammed and augmented catalytic activities hold significant potential in biomedicine. However, common issues with biocatalysts are the presence of numerous inactive site atoms, leading to inefficiencies in their catalytic processes. To leverage the full potential of active catalytic sites, we aim to minimize the biocatalyst structure, transitioning from nanoparticles or polymetallic atomic clusters down to singular-active-unit molecules. In this context, we have developed a unique single active-site cluster molecule, Au1-O5-Na9-(OH)4 (AuO) clusters, comprising a single gold atom, five oxygen atoms, and a protective layer, where Au-O acts as a singular-active site displaying elevated catalytic activities without inefficiencies associated with biocatalytic reactions. AuO clusters demonstrate activities reminiscent of nicotinamide adenine dinucleotide oxidase (NOX), glutathione peroxidase (GPx), and urease, among other oxidoreductase functions, through optimal utilization of atoms. Clusters are instrumental in enhancing the redox balance, mitigating inflammation, and averting inflammation-induced cellular apoptosis, thereby preserving immune balance in sepsis. These mechanisms are crucial in sepsis pathogenesis. Demonstrating GPx-like and NOX-like capabilities, the AuO clusters have shown remarkable effectiveness against lipopolysaccharide-induced and cecum ligation puncture-induced multiorgan damage, underscoring their substantial promise for sepsis management.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.