Electrochemical biosensors for point-of-care testing

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Jinsol Kim, Juho Jeong, Seung Hwan Ko
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引用次数: 0

Abstract

Point-of-care testing (POCT) is the practice of diagnosing and monitoring diseases where the patient is located, as opposed to traditional treatment conducted solely in a medical laboratory or other clinical setting. POCT has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical testing. However, recent growth has occurred in this field due to advances in diagnostic technologies, device miniaturization, and progress in wearable electronics. Among these developments, electrochemical sensors have attracted interest in the POCT field due to their high sensitivity, compact size, and affordability. They are used in various applications, from disease diagnosis to health status monitoring. In this paper we explore recent advancements in electrochemical sensors, the methods of fabricating them, and the various types of sensing mechanisms that can be used. Furthermore, we delve into methods for immobilizing specific biorecognition elements, including enzymes, antibodies, and aptamers, onto electrode surfaces and how these sensors are used in real-world POCT settings.

Graphic abstract

Abstract Image

用于床旁检测的电化学生物传感器
护理点检测(POCT)是在病人所在的地方诊断和监测疾病的做法,有别于仅在医学实验室或其他临床环境中进行的传统治疗。由于缺乏能够促进有效医疗检测的便携式医疗设备,POCT 近来并不常见。然而,由于诊断技术的进步、设备的微型化和可穿戴电子设备的发展,这一领域最近出现了增长。在这些发展中,电化学传感器因其灵敏度高、体积小、价格低廉而在 POCT 领域备受关注。从疾病诊断到健康状况监测,电化学传感器被广泛应用于各种领域。在本文中,我们将探讨电化学传感器的最新进展、制造方法以及可使用的各类传感机制。此外,我们还深入探讨了将特定生物识别元素(包括酶、抗体和适配体)固定到电极表面的方法,以及这些传感器在实际 POCT 环境中的应用。
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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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