{"title":"Anti-Aging Medicine: Mitochondria-Targeted Antioxidants and Physical Activity","authors":"G. A. Shilovsky, E. V. Sorokina, D. N. Akhaev","doi":"10.1134/s2079086424600188","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Mitochondria are an important source of reactive oxygen species in skeletal muscles. Mitochondrial dysfunction accompanies the development of age-related human diseases. An increased production of reactive oxygen species contributes to the muscle atrophy caused, for example, by the absence of physical activity. Many regulatory pathways involved in the mitochondrial biogenesis are targets of anti-aging therapy. An active lifestyle and physical exercise prevent age-related damage to mitochondria in skeletal muscles. The use of antioxidants aimed directly at mitochondria is another way to correct the effect of reactive oxygen species. The treatment with mitochondria-targeted antioxidants weakens the mitochondrial degeneration, improves the age-related function of skeletal muscles, and protects the muscles from atrophy. Data are presented on the use of mitochondria-targeted antioxidants and physical exercises to maintain the structural and functional state of mitochondria and on the protection of muscles from sarcopenia.</p>","PeriodicalId":9047,"journal":{"name":"Biology Bulletin Reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology Bulletin Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s2079086424600188","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Mitochondria are an important source of reactive oxygen species in skeletal muscles. Mitochondrial dysfunction accompanies the development of age-related human diseases. An increased production of reactive oxygen species contributes to the muscle atrophy caused, for example, by the absence of physical activity. Many regulatory pathways involved in the mitochondrial biogenesis are targets of anti-aging therapy. An active lifestyle and physical exercise prevent age-related damage to mitochondria in skeletal muscles. The use of antioxidants aimed directly at mitochondria is another way to correct the effect of reactive oxygen species. The treatment with mitochondria-targeted antioxidants weakens the mitochondrial degeneration, improves the age-related function of skeletal muscles, and protects the muscles from atrophy. Data are presented on the use of mitochondria-targeted antioxidants and physical exercises to maintain the structural and functional state of mitochondria and on the protection of muscles from sarcopenia.
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