Perspectives on biovigilance and transmission of infection of donor origin in deceased organ donation—The evolving scenario in the United Kingdom

IF 2.6 4区医学 Q3 IMMUNOLOGY

Transplant Infectious Disease Pub Date : 2024-07-27 DOI:10.1111/tid.14351

Ines Ushiro‐Lumb, Christie Geoghegan, Olive McGowan, Richard Baker

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Abstract

BackgroundA biovigilance program that has oversight of the entire organ and tissue donation and transplantation pathways underpins the quality and safety system in the United Kingdom.MethodA synopsis of the microbiological characterization of potential deceased organ donors and the processes for notification and investigation of possible donor‐derived infections are described. A summary of the outcome of investigations performed over a 10‐year period and a subset data frame of 5 years showing the proportion of infection incidents in relation to other incident types are also presented.ConclusionA single, centralized system overseeing the entire donation and transplantation pathway has become an essential part of transplantation practice across the United Kingdom. Revision of processes and management options, awareness of clinical conditions, and review of guidance are some examples of benefits gained over time. Transmission figures provided reflect the UK setting; these should be interpreted in context, as donor and recipient epidemiology differs across regions and nations. Despite a well‐established system in place, under reporting of cases continues to occur, with ongoing efforts to reassure professionals and patients of the true benefits of biovigilance in driving improvements in practice and patient outcomes.

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对生物警戒和已故器官捐献中捐献者源性感染传播的展望--英国不断变化的情况

背景对整个器官和组织捐献及移植途径进行监督的生物警戒计划是英国质量和安全系统的基础。方法简要介绍了潜在已故器官捐献者的微生物特征以及对可能的捐献者感染进行通知和调查的流程。此外，还介绍了 10 年间的调查结果摘要和 5 年的子集数据框架，其中显示了感染事件与其他事件类型的比例。对流程和管理方案的修订、对临床情况的了解以及对指南的审查是随着时间推移而获得的一些益处。所提供的传播数字反映的是英国的情况；由于不同地区和国家的捐献者和受者流行病学情况各不相同，因此在解释这些数字时应结合实际情况。尽管已经建立了完善的系统，但病例报告不足的情况仍时有发生，我们将继续努力，让专业人士和患者确信生物警戒在推动改进实践和患者治疗效果方面的真正益处。图像

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplant Infectious Disease 医学-传染病学

CiteScore

5.30

自引率

7.70%

发文量

210

审稿时长

4-8 weeks

期刊介绍： Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal. Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.