Efficacy, Satisfaction, and Compliance: Insights from 15 Years of Botulinum Toxin Use for Female Urgency Urinary Incontinence

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Toxins Pub Date : 2024-07-26 DOI:10.3390/toxins16080332

Margarida Manso, João Diogo Soares, Margarida Henriques, Francisco Botelho, Carlos Silva, Francisco Cruz

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引用次数: 0

Abstract

Urgency urinary incontinence (UUI) refractory to medical treatment poses significant challenges despite advancements. This study evaluates the efficacy of intravesical botulinum toxin for UUI and identifies factors influencing treatment outcomes. Among 368 women receiving botulinum toxin injections, 74.5% achieved a complete discontinuation of pad usage. Predictors of efficacy included lower pre-treatment pad usage and the absence of prior sling placement. Patients often required repeat injections (60.3%), with younger age and satisfaction correlating with treatment repetition. The interval between injections averaged 18 months, influenced by logistical challenges and patient preferences. Despite concerns about diminishing efficacy, subjective perceptions did not align with objective findings. Limitations include retrospective analysis and heterogeneous clinical records. In conclusion, intravesical botulinum toxin is effective for UUI, with pre-treatment pad usage and sling placement history influencing outcomes and patient characteristics influencing treatment repetition.

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疗效、满意度和依从性：肉毒杆菌毒素治疗女性急迫性尿失禁 15 年的启示

急迫性尿失禁（UUI）是医学治疗的难治之症，尽管治疗技术不断进步，但仍面临巨大挑战。本研究评估了膀胱内注射肉毒杆菌毒素治疗尿失禁的疗效，并确定了影响治疗效果的因素。在接受肉毒杆菌毒素注射的 368 名妇女中，74.5% 的人完全停止使用尿垫。疗效的预测因素包括治疗前较低的尿垫使用量和之前未放置吊带。患者通常需要重复注射（60.3%），年龄越小、满意度越高与重复治疗越有关系。受后勤挑战和患者偏好的影响，注射间隔平均为 18 个月。尽管存在疗效下降的担忧，但主观感受与客观结果并不一致。不足之处包括回顾性分析和不同的临床记录。总之，膀胱内注射肉毒杆菌毒素对尿道前列腺肥大是有效的，治疗前垫子的使用和吊带的放置历史会影响治疗效果，患者的特征会影响治疗的重复性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxins TOXICOLOGY-

CiteScore

7.50

自引率

16.70%

发文量

765

审稿时长

16.24 days

期刊介绍： Toxins (ISSN 2072-6651) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to toxins and toxinology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.