M. S. Fedorova, A. E. Gatina, V. N. Ilyina, L. L. Yadykova, V. V. Drukker, A. S. Gorshkova, A. R. Kayumov, E. Y. Trizna
{"title":"A New Bacteriophage Pseudomonas Phage Ka1 from a Tributary Stream of Lake Baikal","authors":"M. S. Fedorova, A. E. Gatina, V. N. Ilyina, L. L. Yadykova, V. V. Drukker, A. S. Gorshkova, A. R. Kayumov, E. Y. Trizna","doi":"10.1134/s0026261723604906","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The bacteriophage <i>Pseudomonas</i> phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the <i>Pseudomonas</i> phage PSA37 genome, belonging to <i>Bruynoghevirus</i> from the class <i>Caudoviricetes</i> suggesting that Ka1 is a new representative of Luz24-like phages (<i>Bruynoghevirus</i>). The bacteriophage lyzes 62% of <i>P. aeruginosa</i> clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage <i>Pseudomonas</i> phage Ka1; which allows using it in the complex therapy of infections caused by <i>P. aeruginosa.</i></p>","PeriodicalId":18514,"journal":{"name":"Microbiology","volume":"2 1","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s0026261723604906","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The bacteriophage Pseudomonas phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the Pseudomonas phage PSA37 genome, belonging to Bruynoghevirus from the class Caudoviricetes suggesting that Ka1 is a new representative of Luz24-like phages (Bruynoghevirus). The bacteriophage lyzes 62% of P. aeruginosa clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage Pseudomonas phage Ka1; which allows using it in the complex therapy of infections caused by P. aeruginosa.
期刊介绍：
Microbiology is an is an international peer reviewed journal that covers a wide range of problems in the areas of fundamental and applied microbiology. The journal publishes experimental and theoretical papers, reviews on modern trends in different fields of microbiological science, and short communications with descriptions of unusual observations. The journal welcomes manuscripts from all countries in the English or Russian language.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
