Connection between Hexuronate Metabolism and the Ability of Escherichia coli to Adhesion and Biofilm Formation

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-26 DOI:10.1134/s002626172460472x

T. A. Bessonova, U. D. Kuznetsova, A. T. Magkaev, M. S. Gelfand, O. N. Ozoline, M. N. Tutukina

引用次数: 0

Abstract

The formation of bacterial biofilms is an important factor of the chronic infection development, which requires the search for effective ways to prevent it. Here, it was found that hexuronates did not affect the biofilm formation by the probiotic strain Escherichia coli Nissle 1917 and its adhesive properties but reduced the efficiency of biofilm formation by the E. coli K-12 MG1655 strain, enhancing its adhesion to human intestinal carcinoma cells. Regulators of hexuronate metabolism, UxuR and YjjM, were shown to be involved, along with cAMP-CRP, in the control of motility, adhesion and biofilm formation of E. coli K-12 MG1655. In addition, untranslated RNAs encoded in the uxuR gene play an important role inhibiting the main sigma factor of motility.

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己酮酸盐代谢与大肠杆菌粘附和生物膜形成能力之间的联系

摘要细菌生物膜的形成是慢性感染发展的一个重要因素，因此需要寻找有效的方法来预防。研究发现，己酮酸盐不影响益生菌大肠杆菌 Nissle 1917 菌株生物膜的形成及其粘附性，但降低了大肠杆菌 K-12 MG1655 菌株生物膜形成的效率，增强了其对人类肠癌细胞的粘附性。研究表明，己酮酸代谢调节因子 UxuR 和 YjjM 与 cAMP-CRP 一起参与了对大肠杆菌 K-12 MG1655 的运动、粘附和生物膜形成的控制。此外，uxuR 基因编码的非翻译 RNA 在抑制运动的主要 sigma 因子方面发挥了重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.