Assessment of bidirectional impact of stigmatization induced self-medication on COVID-19 and malaria transmissions using mathematical modeling: Nigeria as a case study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-24 DOI:10.1016/j.mbs.2024.109249

Wisdom S. Avusuglo , Qing Han , Woldegebriel Assefa Woldegerima , Ali Asgary , Jianhong Wu , James Orbinski , Nicola Bragazzi , Ali Ahmadi , Jude Dzevela Kong

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引用次数: 0

Abstract

The continual social and economic impact of infectious diseases on nations has maintained sustained attention on their control and treatment, of which self-medication has been one of the means employed by some individuals. Self-medication complicates the attempt of their control and treatment as it conflicts with some of the measures implemented by health authorities. Added to these complications is the stigmatization of individuals with some diseases in some jurisdictions. This study investigates the co-infection of COVID-19 and malaria and its related deaths and further highlights how self-medication and stigmatization add to the complexities of the fight against these two diseases using Nigeria as a study case. Using a mathematical model on COVID-19 and malaria co-infection, we address the question: to what degree does the impact of the interaction between COVID-19 and malaria amplify infections and deaths induced by both diseases via self-medication and stigmatization? We demonstrate that COVID-19 related self-medication due to misdiagnoses contributes substantially to the prevalence of disease. The control reproduction numbers for these diseases and quantification of model parameters uncertainties and sensitivities are presented.

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利用数学建模评估污名化引起的自我药疗对 COVID-19 和疟疾传播的双向影响：以尼日利亚为例。

传染病对各国社会和经济的持续影响使人们持续关注传染病的控制和治疗，其中自我药疗是一些人采用的手段之一。自我药疗与卫生当局实施的某些措施相冲突，使控制和治疗工作变得更加复杂。除了这些复杂情况之外，在某些地区，患有某些疾病的人还会受到鄙视。本研究以尼日利亚为研究案例，调查了 COVID-19 和疟疾的合并感染及其相关死亡情况，并进一步强调了自我药疗和污名化是如何增加这两种疾病防治工作的复杂性的。利用 COVID-19 和疟疾合并感染的数学模型，我们解决了这样一个问题：COVID-19 和疟疾之间的相互作用在多大程度上通过自我药疗和污名化放大了这两种疾病引起的感染和死亡？我们证明，因误诊而导致的与 COVID-19 相关的自行用药在很大程度上加剧了疾病的流行。本文介绍了这些疾病的控制繁殖数量以及模型参数不确定性和敏感性的量化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.