Prognostic significance of hemorrhage requiring embolization in the setting of previously treated head and neck squamous cell carcinoma: Systematic review and retrospective cohort.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-07-26 DOI:10.1002/hed.27875

Omar A Karadaghy, Andrew M Peterson, Tuleen Sawaf, Bryan Renslo, Brevin Miller, Celina Virgen, Kevin J Sykes, Michelle M Doering, Christopher J Moran, Henrik Ullman, Jeremy Peterson, Patrik Pipkorn, Andrés M Bur

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引用次数: 0

Abstract

Background: The management of acute hemorrhage in patients with previously treated head and neck squamous cell carcinoma (HNSCC) is challenging due to the lack of substantial evidence to guide clinical decision making.

Methods: A systematic review and retrospective chart review were performed to identify patients with a history of HNSCC who underwent either primary or adjuvant radiation therapy (RT) and presented with hemorrhagic complications requiring embolization. Patient characteristics, history, presentation, and outcomes were reviewed.

Results: The systematic review included a total of 182 patients. Heterogeneity existed in outcomes reporting; 1-year overall survival approached 50%. From the retrospective chart review, 51 patients were included. Median survival time following hemorrhage was 2.2 months (range 1.2-11.4 months). Patients with malignancy at time of hemorrhage were identified as having worse survival.

Conclusions: Acute hemorrhage in patients with a history of previously radiated HNSCC portends a high risk of mortality, with patients with active malignancy representing a worse prognostic group.

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曾接受过头颈部鳞状细胞癌治疗的患者发生需要栓塞的出血的预后意义：系统回顾和回顾性队列。

背景：头颈部鳞状细胞癌（HNSCC）患者急性出血的治疗方法具有挑战性：由于缺乏大量证据来指导临床决策，如何处理曾接受过头颈部鳞状细胞癌（HNSCC）治疗的患者的急性出血问题具有挑战性：方法：我们通过系统回顾和回顾性病历来确定接受过原发性或辅助性放射治疗（RT）并出现需要栓塞治疗的出血并发症的 HNSCC 患者。对患者的特征、病史、表现和结果进行了回顾：结果：系统回顾共纳入了 182 例患者。结果报告存在异质性；1年总生存率接近50%。回顾性病历审查纳入了 51 例患者。大出血后的中位生存时间为 2.2 个月（1.2-11.4 个月）。出血时患有恶性肿瘤的患者生存率较低：结论：曾接受过放射治疗的HNSCC患者发生急性出血预示着较高的死亡风险，其中恶性肿瘤处于活动期的患者预后较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.