Difficult to treat Pseudomonas: successful salvage therapy with cefepime-zidebactam.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-02 DOI:10.1093/trstmh/trae049

Anjely Sebastian, Shivdas Naik, Muralidhar Varma, N C Sreekumar, Joseph Thomas, Tanvi Rao, Birva J Shah, Nitin Gupta

引用次数: 0

Abstract

Carbapenem-resistant Pseudomonas aeruginosa (CRPa) infection is extremely challenging to manage. Cefepime-zidebactam is a novel combination that can be considered for salvage therapy when no other antimicrobials are susceptible. A 15-y-old boy presented with 56% thermal burns, followed by skin and soft tissue infection, secondary bacteraemia, complicated parapneumonic effusion and endophthalmitis due to CRPa, which was not susceptible to any of the routinely available antibiotics. He was treated with cefepime-zidebactam for 45 d, with which he recovered.

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难以治疗的假单胞菌：头孢吡肟-齐德巴坦的成功挽救疗法。

耐碳酸培南铜绿假单胞菌（CRPa）感染的治疗极具挑战性。头孢吡肟-齐德巴坦是一种新型复方制剂，在没有其他抗菌药物敏感的情况下，可考虑用于抢救治疗。一名 15 岁的男孩因 56% 的热烧伤，继而出现皮肤和软组织感染、继发性菌血症、并发症性肺旁积液和眼内炎，病因是对任何常规抗生素都不敏感的 CRPa。他接受了为期 45 天的头孢吡肟-齐德巴坦治疗，随后痊愈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.