Ambient PM_2.5 components might exacerbate bone loss among middle-aged and elderly women: evidence from a population-based cross-sectional study.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2024-10-01 Epub Date: 2024-07-26 DOI:10.1007/s00420-024-02090-y

Faxue Zhang, Shijie Zhu, Yanfeng Di, Minghao Pan, Wei Xie, Xugui Li, Wei Zhu

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引用次数: 0

Abstract

Background: Previous studies have primarily focused on the links between fine particulate matter (PM_2.5) and bone health among the general population instead of PM_2.5 components and the specific population. We aimed to investigate the associations between PM_2.5 components and bone health among middle-aged and elderly women.

Methods: A total of 748 middle-aged and elderly women were randomly sampled from 32 streets/villages in Hubei Province. The concentrations of ambient PM_2.5 and its components were extracted across various residential areas from the Tracking Air Pollution in China (TAP) dataset. Bone mineral density measurements were obtained from dual-energy X-ray absorptiometry scans of study participants. Multivariable logistic and linear models were employed to assess the relationship between PM_2.5 and its components and bone loss.

Results: Per interquartile range (IQR) increase in nitrate (NO₃^-) and ammonium (NH₄⁺) concentrations were associated with 1.65 [95% confidence intervals (CI): 1.13, 2.30] and 1.77 (95% CI: 1.26, 2.49) times higher odds of osteoporosis, respectively. Long-term exposure to sulfate (SO₄^2-), NO₃^-, and NH₄⁺ was negatively associated with T-scores and bone mineral density in L1-L4 lumbar vertebrae. In addition, the elderly, women who have experienced menarche after the age of 14, and postmenopausal women were more susceptible to the water-soluble inorganic salts of PM_2.5.

Conclusion: The study emphasizes the need for comprehensive policies addressing air quality, with a specific focus on vulnerable populations such as middle-aged and elderly women. Public health interventions aimed at reducing ambient PM_2.5 concentrations and minimizing exposure to its harmful components are crucial in mitigating the adverse impact on skeletal health and improving the overall well-being of communities.

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环境 PM2.5 成分可能会加剧中老年妇女的骨质流失：一项基于人群的横断面研究提供的证据。

背景：以往的研究主要集中于普通人群中细颗粒物（PM2.5）与骨骼健康之间的联系，而不是PM2.5成分与特定人群之间的联系。我们旨在调查中老年妇女中 PM2.5 成分与骨骼健康之间的关系：方法：从湖北省 32 个街道/村随机抽取 748 名中老年妇女。从中国空气污染追踪（TAP）数据集中提取了不同居民区的环境 PM2.5 浓度及其组分。研究参与者的骨矿密度测量值来自双能 X 射线吸收测量扫描。采用多变量逻辑模型和线性模型评估PM2.5及其成分与骨质流失之间的关系：硝酸盐（NO3-）和铵（NH4+）浓度每增加一个四分位数间距（IQR），骨质疏松症发生几率分别增加 1.65 [95% 置信区间 (CI)：1.13, 2.30] 倍和 1.77 (95% CI：1.26, 2.49)倍。长期暴露于硫酸盐（SO42-）、NO3- 和 NH4+ 与 L1-L4 腰椎的 T 值和骨矿密度呈负相关。此外，老年人、14 岁后初潮的妇女和绝经后妇女更容易受到 PM2.5 中水溶性无机盐的影响：这项研究强调了制定全面的空气质量政策的必要性，并特别关注中老年妇女等弱势群体。旨在降低环境 PM2.5 浓度和尽量减少接触其有害成分的公共卫生干预措施，对于减轻对骨骼健康的不利影响和改善社区的整体福祉至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.