Non-exercise estimated cardiorespiratory fitness and incident type 2 diabetes in adults

IF 6.1 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
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Abstract

Aim(s)

To examine the association between non-exercise estimated cardiorespiratory fitness (eCRF) and incident type 2 diabetes.

Methods

In a sample of 13,616 men and women without diabetes at baseline, incident type 2 diabetes were determined as fasting plasma glucose level ≥ 7 mmol/l (126 mg/dL), self-report, or insulin usage at follow-up. eCRF was calculated in metabolic equivalents (METs) at baseline using sex-specific algorithms, including physical activity, smoking status, age, body mass index, waist circumference, and resting heart rate. Cox regression models were performed, and hazard ratios (HRs), 95 % confidence intervals (CIs), and p values were reported.

Results

Each 1-MET unit increase in eCRF was associated with an 11 % lower risk of incident type 2 diabetes (p < 0.0001). Men in the upper and middle eCRF tertiles were at 46 % (95 % CI, 0.42–0.68) and 29 % (95 % CI, 0.57–0.88) lower risk of incident type 2 diabetes compared to the lower eCRF tertile (p < 0.0001). For women, there were no significant findings between eCRF tertiles and incident type 2 diabetes (p ≥ 0.11 for all).

Conclusions

Higher eCRF was associated with a lower incidence of type 2 diabetes in men. Further research needs to examine the association between eCRF and type 2 diabetes in women.

Abstract Image

非运动估计心肺功能与成人 2 型糖尿病发病率。
目的研究非运动估计心肺功能(eCRF)与2型糖尿病发病率之间的关系:在 13,616 名基线时未患糖尿病的男性和女性样本中,2 型糖尿病的发病率以空腹血浆葡萄糖水平≥ 7 mmol/l (126 mg/dL)、自我报告的 2 型糖尿病或随访时使用胰岛素为标准。eCRF 采用性别特异性算法计算基线时的代谢当量 (MET),包括体力活动、吸烟状况、年龄、体重指数、腰围和静息心率。结果显示,每增加 1 个 MET 单位,体重就会增加 1%:结果:eCRF 每增加 1-MET 单位,2 型糖尿病发病风险降低 11%(p 结论:eCRF 越高,2 型糖尿病发病风险越低:较高的 eCRF 与较低的男性 2 型糖尿病发病率有关。需要进一步研究女性 eCRF 与 2 型糖尿病之间的关系。
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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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