{"title":"Host–Guest Strategy for Organic Phosphorescence to Generate Oxygen Radical over Singlet Oxygen","authors":"Lingling Kang, Cong Chao, Chenchen Xiong, Shuang Yu, Changtao Xiao, Changsheng Zhao, Shisheng Cui, Jiguang Li, Jing Li, Jianbing Shi, Bin Tong, Zhuo Wang, Yin Song, Weiqian Zhao, Zhengxu Cai, Yuping Dong","doi":"10.1021/acs.chemmater.4c01257","DOIUrl":null,"url":null,"abstract":"Exciton dynamics exert a pivotal role in the photodynamic efficiency of photosensitizers, however, strategies for modulating exciton dynamics to motivate electron transfer in exciton-involved photoreactions remain largely unexplored. Herein, we employed a cutting-edge microfluidic platform combined with computational fluid dynamics to encapsulate a commercial type II PS [rose Bengal (RB)] within a rigid host matrix. This encapsulation yielded host/RB nanoparticles (NPs) with a uniform structure and controllable size. The photoexcited dynamics of these host/RB NPs were characterized using time-resolved spectroscopy, and the results revealed that encapsulation not only extended the triplet exciton lifetime of RB, but also created an optimized environment to motivate electron transfer between RB molecules. These findings rationalize the observed remarkable 20-fold reduction in type II photoreaction and a 3-fold promotion in type I photoreaction for host/RB NPs. Due to the dramatic generation of HO<sup>•</sup> and O<sub>2</sub><sup>•–</sup>, host/RB NPs demonstrated excellent ability for the in vitro eradication of <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> biofilms and the in vivo treatment of <i>S. aureus</i>-infected wounds under hypoxia, with a minimum killing concentration of 10<sup>–7</sup> M. This work sheds light on the motivation of exciton transfer to develop type I PS with enhanced photodynamic properties.","PeriodicalId":33,"journal":{"name":"Chemistry of Materials","volume":null,"pages":null},"PeriodicalIF":7.2000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acs.chemmater.4c01257","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Exciton dynamics exert a pivotal role in the photodynamic efficiency of photosensitizers, however, strategies for modulating exciton dynamics to motivate electron transfer in exciton-involved photoreactions remain largely unexplored. Herein, we employed a cutting-edge microfluidic platform combined with computational fluid dynamics to encapsulate a commercial type II PS [rose Bengal (RB)] within a rigid host matrix. This encapsulation yielded host/RB nanoparticles (NPs) with a uniform structure and controllable size. The photoexcited dynamics of these host/RB NPs were characterized using time-resolved spectroscopy, and the results revealed that encapsulation not only extended the triplet exciton lifetime of RB, but also created an optimized environment to motivate electron transfer between RB molecules. These findings rationalize the observed remarkable 20-fold reduction in type II photoreaction and a 3-fold promotion in type I photoreaction for host/RB NPs. Due to the dramatic generation of HO• and O2•–, host/RB NPs demonstrated excellent ability for the in vitro eradication of Staphylococcus aureus and Escherichia coli biofilms and the in vivo treatment of S. aureus-infected wounds under hypoxia, with a minimum killing concentration of 10–7 M. This work sheds light on the motivation of exciton transfer to develop type I PS with enhanced photodynamic properties.
期刊介绍:
The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.