Predictors of Depressive Symptoms in Autistic Youth-A Longitudinal Study From the Province of Ontario Neurodevelopmental Disorders (POND) Network: Prédicteurs des symptômes dépressifs chez les jeunes autistes-une étude longitudinale du Réseau des troubles neurodéveloppementaux de la province de l'Ontario (réseau POND).

IF 3.3 3区 医学 Q2 PSYCHIATRY
Avery Longmore, Evdokia Anagnostou, Stelios Georgiages, Jessica Jones, Elizabeth Kelley, Danielle Baribeau
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引用次数: 0

Abstract

Objective: The objective of this study was to identify longitudinal predictors of depressive symptoms in autistic children and youth.

Methods: Participants were youth with a diagnosis of autism who were part of the Province of Ontario Neurodevelopmental Disorders Network longitudinal substudy. Depressive symptoms were assessed using the child behaviour checklist (CBCL) affective problems subscale. Univariate and multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between clinical and demographic characteristics at baseline (T1) and clinically elevated depressive symptoms (CEDS) approximately 4 years later (T2).

Results: The mean age of participants (n = 75) at T1 was 9.8 years (SD = 2.7) and at T2 was 14.1 years (SD = 2.8). A total of 37% and 35% of participants had CEDS at T1 and T2, respectively. Additionally, 24% of participants had CEDS at both T1 and T2. T1 characteristics associated with T2 CEDS were: loneliness (OR = 3.0, 95% CI, 1.1 to 8.8), self-harm (OR = 4.0, 95% CI, 1.1 to 16.9), suicidal ideation (OR = 3.9, 95% CI, 1.0 to 16.5), more social and adaptive skills (OR = 0.3, 95% CI, 0.1 to 0.9), elevated restricted and repetitive behaviours (OR = 3.8, 95% CI, 1.3 to 11.6), psychotropic medication use (OR = 3.0, 95% CI, 1.1 to 8.4), attention-deficient/hyperactivity disorder (OR = 2.8, 95% CI, 1.1 to 7.8), and T1 CEDS (OR = 8.8, 95% CI, 3.1 to 27.0) (uncorrected for multiple comparisons). Associations persisted after adjusting for age and intelligence quotient (IQ) differences. Age, sex, IQ, teasing/bullying on the CBCL, family psychiatric history and family income were not associated with T2 CEDS.

Conclusion: Our results highlight both high prevalence and high potential for the persistence of depressive symptoms in autism and emphasize the importance of early support to address loneliness and social participation.

自闭症青少年抑郁症状的预测因素--来自安大略省神经发育障碍 (POND) 网络的纵向研究》(Predictors of Depressive Symptoms in Autistic Youth-A Longitudinal Study From the Province of Ontario Neurodevelopmental Disorders (POND) Network)。
目的:本研究旨在确定自闭症儿童和青少年抑郁症状的纵向预测因素:本研究旨在确定自闭症儿童和青少年抑郁症状的纵向预测因素:研究对象为被诊断患有自闭症的青少年,他们是安大略省神经发育障碍网络纵向子研究的一部分。抑郁症状采用儿童行为检查表(CBCL)情感问题分量表进行评估。采用单变量和多变量逻辑回归模型估算基线(T1)时临床和人口统计学特征与约4年后(T2)临床抑郁症状(CEDS)升高之间的几率比(OR)和95%置信区间(CI):参与者(75 人)T1 的平均年龄为 9.8 岁(SD = 2.7),T2 的平均年龄为 14.1 岁(SD = 2.8)。分别有37%和35%的参与者在T1和T2时患有CEDS。此外,24%的参与者在T1和T2时均患有CEDS。与 T2 CEDS 相关的 T1 特征有:孤独(OR = 3.0,95% CI,1.1 至 8.8)、自残(OR = 4.0,95% CI,1.1 至 16.9)、自杀意念(OR = 3.9,95% CI,1.0 至 16.5)、更多的社交和适应技能(OR = 0.3,95% CI,0.1 至 0.9)、受限和重复性行为增加(OR = 0.3,95% CI,0.1 至 0.9)。9)、受限和重复行为增加(OR = 3.8,95% CI,1.3 至 11.6)、精神药物使用(OR = 3.0,95% CI,1.1 至 8.4)、注意力缺陷/多动障碍(OR = 2.8,95% CI,1.1 至 7.8)和 T1 CEDS(OR = 8.8,95% CI,3.1 至 27.0)(未校正多重比较)。调整年龄和智商(IQ)差异后,相关性依然存在。年龄、性别、智商、CBCL中的捉弄/欺凌、家族精神病史和家庭收入与T2 CEDS无关:我们的研究结果凸显了自闭症患者抑郁症状的高患病率和持续存在的高潜力,并强调了早期支持以解决孤独和社会参与问题的重要性。
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来源期刊
CiteScore
7.00
自引率
2.50%
发文量
69
审稿时长
6-12 weeks
期刊介绍: Established in 1956, The Canadian Journal of Psychiatry (The CJP) has been keeping psychiatrists up-to-date on the latest research for nearly 60 years. The CJP provides a forum for psychiatry and mental health professionals to share their findings with researchers and clinicians. The CJP includes peer-reviewed scientific articles analyzing ongoing developments in Canadian and international psychiatry.
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