Altered neural synchronization in response to 2 Hz amplitude-modulated tones in the auditory cortex of children with Autism Spectrum Disorder: An MEG study

IF 2.5 3区心理学 Q3 NEUROSCIENCES

International Journal of Psychophysiology Pub Date : 2024-07-23 DOI:10.1016/j.ijpsycho.2024.112405

Ilya Samoylov , Giorgio Arcara , Irina Buyanova , Elizaveta Davydova , Darya Pereverzeva , Alexander Sorokin , Svetlana Tyushkevich , Uliana Mamokhina , Kamilla Danilina , Olga Dragoy , Vardan Arutiunian

{"title":"Altered neural synchronization in response to 2 Hz amplitude-modulated tones in the auditory cortex of children with Autism Spectrum Disorder: An MEG study","authors":"Ilya Samoylov , Giorgio Arcara , Irina Buyanova , Elizaveta Davydova , Darya Pereverzeva , Alexander Sorokin , Svetlana Tyushkevich , Uliana Mamokhina , Kamilla Danilina , Olga Dragoy , Vardan Arutiunian","doi":"10.1016/j.ijpsycho.2024.112405","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Some studies have hypothesized that atypical neural synchronization at the delta frequency band in the auditory cortex is associated with phonological and language skills in children with Autism Spectrum Disorder (ASD), but it is still poorly understood. This study investigated this neural activity and addressed the relationships between auditory response and behavioral measures of children with ASD.</p></div><div><h3>Methods</h3><p>We used magnetoencephalography and individual brain models to investigate 2 Hz Auditory Steady-State Response (ASSR) in 20 primary-school-aged children with ASD and 20 age-matched typically developing (TD) controls.</p></div><div><h3>Results</h3><p>First, we found a between-group difference in the localization of the auditory response, so as the topology of 2 Hz ASSR was more superior and posterior in TD children when comparing to children with ASD. Second, the power of 2 Hz ASSR was reduced in the ASD group. Finally, we observed a significant association between the amplitude of neural response and language skills in children with ASD.</p></div><div><h3>Conclusions</h3><p>The study provided the evidence of reduced neural response in children with ASD and its relation to language skills.</p></div><div><h3>Significance</h3><p>These findings may inform future interventions targeting auditory and language impairments in ASD population.</p></div>","PeriodicalId":54945,"journal":{"name":"International Journal of Psychophysiology","volume":"203 ","pages":"Article 112405"},"PeriodicalIF":2.5000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychophysiology","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167876024001090","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Some studies have hypothesized that atypical neural synchronization at the delta frequency band in the auditory cortex is associated with phonological and language skills in children with Autism Spectrum Disorder (ASD), but it is still poorly understood. This study investigated this neural activity and addressed the relationships between auditory response and behavioral measures of children with ASD.

Methods

We used magnetoencephalography and individual brain models to investigate 2 Hz Auditory Steady-State Response (ASSR) in 20 primary-school-aged children with ASD and 20 age-matched typically developing (TD) controls.

Results

First, we found a between-group difference in the localization of the auditory response, so as the topology of 2 Hz ASSR was more superior and posterior in TD children when comparing to children with ASD. Second, the power of 2 Hz ASSR was reduced in the ASD group. Finally, we observed a significant association between the amplitude of neural response and language skills in children with ASD.

Conclusions

The study provided the evidence of reduced neural response in children with ASD and its relation to language skills.

Significance

These findings may inform future interventions targeting auditory and language impairments in ASD population.

查看原文本刊更多论文

ASD 儿童听觉皮层对 2 赫兹音调的神经同步反应发生改变：MEG 研究。

研究目的一些研究假设，听觉皮层中δ频段的非典型神经同步与自闭症谱系障碍（ASD）儿童的语音和语言能力有关，但人们对这一假设的了解仍然很少。本研究调查了这一神经活动，并探讨了自闭症谱系障碍儿童听觉反应与行为测量之间的关系：方法：我们使用脑磁图和个体脑模型研究了20名小学年龄的ASD儿童和20名年龄匹配的典型发育（TD）对照组儿童的2赫兹听觉稳态反应（ASSR）：首先，我们发现听觉反应的位置存在组间差异，与ASD儿童相比，TD儿童的2 Hz听觉稳态反应的拓扑结构更靠上和靠后。其次，ASD 组 2 Hz ASSR 的功率降低。最后，我们观察到 ASD 儿童的神经反应振幅与语言能力之间存在明显关联：本研究提供了 ASD 儿童神经反应减弱及其与语言能力关系的证据：这些发现可为未来针对 ASD 儿童听觉和语言障碍的干预措施提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Psychophysiology 医学-神经科学

CiteScore

5.40

自引率

10.00%

发文量

177

审稿时长

3-8 weeks

期刊介绍： The International Journal of Psychophysiology is the official journal of the International Organization of Psychophysiology, and provides a respected forum for the publication of high quality original contributions on all aspects of psychophysiology. The journal is interdisciplinary and aims to integrate the neurosciences and behavioral sciences. Empirical, theoretical, and review articles are encouraged in the following areas: • Cerebral psychophysiology: including functional brain mapping and neuroimaging with Event-Related Potentials (ERPs), Positron Emission Tomography (PET), Functional Magnetic Resonance Imaging (fMRI) and Electroencephalographic studies. • Autonomic functions: including bilateral electrodermal activity, pupillometry and blood volume changes. • Cardiovascular Psychophysiology:including studies of blood pressure, cardiac functioning and respiration. • Somatic psychophysiology: including muscle activity, eye movements and eye blinks.