The effect of phototherapy treatment on serum melatonin levels in term newborns.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-05 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5816

Ali Bülbül, İlkay Özmeral Odabaşi, Duygu Besnili Açar, Semra Tiryaki Demir

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引用次数: 0

Abstract

Background/aim: The aim of this study was to investigate the effect of phototherapy treatment on serum melatonin levels in term newborn infants.

Material and methods: This study was planned as a single-center, prospective, observational, case-control study. Term infants (gestation week ≥37 weeks) who received at least 6 h of phototherapy due to jaundice constitute the phototherapy group, while the term infants without jaundice and who were exclusively breastfed constitute the control group. Melatonin levels were examined by taking blood samples from babies in both groups at 02:00 at night. Melatonin values were compared between groups. The effect of phototherapy on serum melatonin levels was investigated. The relationship between the duration of phototherapy and maximum serum bilirubin values on melatonin values was investigated.

Results: Seventy term infants (64.3% girls) were included in the study. Mean gestational week was 38.3 ± 1.1 weeks, mean birth weight was 3295 ± 434 g. There was no statistically significant difference between the phototherapy group and the control group in terms of sex, type of delivery, gestational week, birth weight, height, and head circumference (all p > 0.05). Serum melatonin level was 20.3 ± 5.9 pg/mL (range: 8.7-36.6 pg/mL) in the phototherapy group and 19.9 ± 4.38 pg/mL (range: 9.9-26.3 pg/mL) in the control group. There was no significant difference between the two groups in terms of serum melatonin levels (p = 0.155). The mean total bilirubin value was 17.65 ± 1.48 mg/dL, and the average duration of phototherapy application was 13.94 ± 7.64 h in the babies in the phototherapy group. No correlation was found between the duration of phototherapy application and serum melatonin levels (p = 0.791).

Conclusion: It was determined that there was no significant difference in serum melatonin levels in term newborn babies who received phototherapy for at least 6 h due to jaundice. No correlation was found between the duration of phototherapy application and the serum melatonin level of the maximum bilirubin values.

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光疗对足月儿血清褪黑激素水平的影响。

背景/目的：本研究旨在探讨光疗对足月新生儿血清褪黑激素水平的影响：本研究为单中心、前瞻性、观察性、病例对照研究。因黄疸而接受至少 6 小时光疗的足月新生儿（孕周≥37 周）为光疗组，无黄疸且纯母乳喂养的足月新生儿为对照组。两组婴儿均在夜间 02:00 时抽取血液样本，检测褪黑激素水平。两组婴儿的褪黑激素水平进行了比较。研究了光疗对血清褪黑激素水平的影响。研究了光疗持续时间和血清胆红素最高值对褪黑激素水平的影响：研究共纳入了 70 名足月儿（64.3% 为女婴）。光疗组与对照组在性别、分娩方式、孕周、出生体重、身高和头围方面没有统计学差异（P>0.05）。光疗组的血清褪黑素水平为 20.3 ± 5.9 pg/mL（范围：8.7-36.6 pg/mL），对照组为 19.9 ± 4.38 pg/mL（范围：9.9-26.3 pg/mL）。两组的血清褪黑激素水平无明显差异（P = 0.155）。光疗组婴儿的总胆红素平均值为（17.65 ± 1.48）毫克/分升，光疗平均持续时间为（13.94 ± 7.64）小时。光疗持续时间与血清褪黑激素水平之间没有相关性（P = 0.791）：结论：在因黄疸而接受光疗至少 6 小时的足月新生儿中，血清褪黑激素水平没有明显差异。光疗持续时间与血清褪黑激素水平和胆红素最大值之间没有相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.