Short- and long-term neurological outcomes of congenital cytomegalovirus infection.

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Turkish Journal of Medical Sciences Pub Date : 2024-01-05 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5819
Fatih Mehmet Akif Özdemir, Yasemin Taşçi Yildiz, Rüveyda Gümüşer Cinni, Ayşegül Zenciroğlu, Deniz Yüksel
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引用次数: 0

Abstract

Background/aim: Cytomegalovirus (CMV) is the most common congenital viral infection. Although most children with congenital CMV (approximately 85%-90%) are asymptomatic at birth, findings such as sensorineural hearing loss, microcephaly, and neurodevelopmental retardation can be observed during the follow-up. Among the brain magnetic resonance imaging (MRI) findings of CMV are white matter abnormalities, polymicrogyria, and periventricular calcification. Since a definitive diagnosis of congenital CMV cannot be made after the neonatal period, the identification of the associated phenotype is diagnostically important, but data are limited in patients who have been retrospectively diagnosed with congenital CMV infection. The aim of this study was to evaluate the short- and long-term neurological follow-up results of congenital CMV infections in a tertiary hospital.

Materials and methods: The neurological results of fifteen patients under the age of 18 years, who had a definitive diagnosis of congenital CMV infection and were followed up in a tertiary care hospital between 2011 and 2020, were retrospectively evaluated.

Results: Ten of the patients in our study group were male. The mean age at presentation for neurological evaluation was 2.02 ± 1.54 months, with a median follow-up time of 36.3 months (range: 9.3-129.4 months). Neurological disorders detected during the long-term follow-up included cerebral palsy (46.7%), cognitive impairment (46.7%), epilepsy (40%), and sensorineural hearing loss (26.7%). The most common abnormality observed on MRI scans was white matter involvement (53.3%).

Conclusion: Early diagnosis and intervention are crucial in congenital CMV infection, as it commonly results in neurological involvement among the patients in our series. This preventable condition warrants further research regarding prenatal/neonatal screening.

先天性巨细胞病毒感染对神经系统的短期和长期影响。
背景/目的:巨细胞病毒(CMV)是最常见的先天性病毒感染。虽然大多数先天性巨细胞病毒感染患儿(约 85%-90% )出生时无症状,但随访期间可观察到感音神经性听力损失、小头畸形和神经发育迟缓等症状。CMV 的脑磁共振成像(MRI)结果包括白质异常、多小脑症和脑室周围钙化。由于新生儿期后无法明确诊断先天性 CMV,因此确定相关表型在诊断上非常重要,但回顾性诊断为先天性 CMV 感染的患者的数据非常有限。本研究旨在评估一家三级医院先天性 CMV 感染的短期和长期神经系统随访结果:对 2011 年至 2020 年期间在一家三级医院随访的 15 名明确诊断为先天性 CMV 感染的 18 岁以下患者的神经系统结果进行了回顾性评估:研究组中有 10 名男性患者。接受神经系统评估的平均年龄为(2.02 ± 1.54)个月,中位随访时间为 36.3 个月(范围:9.3-129.4 个月)。长期随访期间发现的神经系统疾病包括脑瘫(46.7%)、认知障碍(46.7%)、癫痫(40%)和感音神经性听力损失(26.7%)。磁共振成像扫描中最常见的异常是白质受累(53.3%):结论:先天性巨细胞病毒感染通常会导致神经系统受累,因此早期诊断和干预对先天性巨细胞病毒感染至关重要。这种可预防的疾病需要进一步研究产前/新生儿筛查。
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来源期刊
Turkish Journal of Medical Sciences
Turkish Journal of Medical Sciences 医学-医学:内科
CiteScore
4.60
自引率
4.30%
发文量
143
审稿时长
3-8 weeks
期刊介绍: Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical  details of a given medical  subspeciality may not be evaluated for publication.
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