Neuroprotective roles of flavonoid "hispidulin" in the central nervous system: A review.

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Saeed Mustapha, Rabiu Abdussalam Magaji, Mohammed Garba Magaji, Ibrahim Bako Gaya, Baraka Umar, Yusuf Yusha'u, Abubakar Bishir Daku, Samaila Musa Chiroma, Aliyu Jaafar, Mohamad Zulfadli Mehat, Che Norma Mat Taib, Mohamad Aris Moh'd Moklas
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引用次数: 0

Abstract

Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of flavonoids. It can be found in different plant materials, especially fruits and vegetables. The literature used in this review was collected from credible scientific databases including ScienceDirect, Scopus, PubMed, Google Scholar, and Hindawi without time restriction, using relevant keywords, such as HN, brain, central nervous system, flavonoids, and flavones. HN was discovered to possess pro-apoptotic properties, act as an antioxidant, inhibit cytokine production and toll-like receptor 4 expression, as well as impede nuclear factor kappa beta and mitogen-activated protein kinase B. HN was also found to inhibit lipid peroxidation in vitro and reduce brain edema in mice. These pharmacological potentials suggest that HN is a promising candidate for neuroprotection in CNS disorders like depression and epilepsy. This review provides an update on the scientific literature concerning how these activities could help provide various forms of neuroprotection in the CNS. Additional experimental data on the effects of HN in models of neurological disorders and neuroprotection should be explored further. Based on the current study, HN is a promising candidate for neuroprotection of the CNS.

黄酮类化合物 "hispidulin "在中枢神经系统中的神经保护作用:综述。
人们对天然植物化学物质的兴趣与日俱增,认为它们可以降低脑部疾病的风险。Hispidulin(HN)是一种酚类黄酮化合物,对中枢神经系统具有多种药理和生物作用。它属于黄酮类黄酮化合物。它存在于不同的植物材料中,尤其是水果和蔬菜。本综述所使用的文献均来自可靠的科学数据库,包括 ScienceDirect、Scopus、PubMed、Google Scholar 和 Hindawi,没有时间限制,并使用了相关关键词,如 HN、大脑、中枢神经系统、类黄酮和黄酮。研究发现 HN 具有促凋亡特性、抗氧化作用、抑制细胞因子的产生和 toll 样受体 4 的表达,以及阻碍核因子 kappa beta 和丝裂原活化蛋白激酶 B。这些药理潜力表明,HN 是一种很有希望用于中枢神经系统疾病(如抑郁症和癫痫)神经保护的候选药物。本综述提供了有关这些活性如何有助于为中枢神经系统提供各种形式的神经保护的最新科学文献。关于 HN 对神经系统疾病和神经保护模型影响的更多实验数据有待进一步探索。根据目前的研究,HN 是一种有希望保护中枢神经系统的候选物质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Basic Medical Sciences
Iranian Journal of Basic Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-PHARMACOLOGY & PHARMACY
CiteScore
4.00
自引率
4.50%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . The Journal of "IJBMS” is a modern forum for scientific communication. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, Microbiology, Pathology, Pharmacology, Pharmaceutical Sciences, and Physiology, will be published after they have been peer reviewed. This will also include reviews and multidisciplinary research.
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