Genetic association of diabetic retinopathy with long noncoding RNA CDKN2B-AS1 gene polymorphism.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-07-26 DOI:10.1177/11206721241266704
Yen-Po Yao, Hsiang-Wen Chien, Kai Wang, Yi-Sun Yang, Shih-Chi Su, Lun-Ching Chang, Hung-Yu Lin, Shun-Fa Yang
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引用次数: 0

Abstract

Aim: We attempted to test the influences of cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) gene polymorphisms on the susceptibility to Diabetic retinopathy (DR).

Methods: Five single-nucleotide polymorphisms (SNPs) of the CDKN2B-AS1 gene, rs564398, rs1333048, rs1537373, rs2151280, and rs8181047 were examined in 280 DR cases and 455 DR-free diabetic controls.

Results: Among these loci tested, we demonstrated that diabetic carriers of at least one polymorphic allele (G) of rs2151280 (AG and GG; AOR, 1.613; 95% CI, 1.040-2.501; p = 0.033) are more susceptible to proliferative DR but not non-proliferative DR. This genetic association with the risk of developing proliferative DR was further strengthened in homozygotes for the polymorphic allele (G) of rs2151280 (GG; AOR, 2.194; 95% CI, 1.117-4.308; p = 0.023). We detected a significant association of the polymorphic allele (G) of rs2151280 with proliferative DR patients (OR, 1.503; 95% CI, 1.112-2.033; p = 0.008) but not with the entire DR or non-proliferative DR group. Moreover, as compared to those who do not possess the polymorphic allele of rs2151280 (AA), DR patients carrying at least one polymorphic allele of rs2151280 (AG + GG) exhibited a lower glomerular filtration rate and HDL cholesterol level, revealing a promotive role of rs2151280 in renal and cardiovascular complications of diabetes.

Conclusion: Taken together, our findings implicate an impact of CDKN2B-AS1 gene polymorphisms on the progression of DR.

糖尿病视网膜病变与长非编码 RNA CDKN2B-AS1 基因多态性的遗传关联
目的:我们试图检测细胞周期蛋白依赖性激酶抑制剂 2B 反义 RNA 1(CDKN2B-AS1)基因多态性对糖尿病视网膜病变(DR)易感性的影响:方法:在280例DR患者和455例无DR的糖尿病对照者中检测了CDKN2B-AS1基因的5个单核苷酸多态性(SNPs),即rs564398、rs1333048、rs1537373、rs2151280和rs8181047:在检测的这些位点中,我们发现 rs2151280(AG 和 GG;AOR,1.613;95% CI,1.040-2.501;p = 0.033)中至少有一个多态等位基因(G)的糖尿病携带者更易患增殖性 DR,而非增殖性 DR。在 rs2151280 的多态等位基因(G)(GG;AOR,2.194;95% CI,1.117-4.308;p = 0.023)的同基因人中,这种与增殖性 DR 发病风险的遗传关联进一步加强。我们发现,rs2151280 的多态等位基因 (G) 与增殖性 DR 患者有显著关联(OR,1.503;95% CI,1.112-2.033;p = 0.008),但与整个 DR 或非增殖性 DR 组没有关联。此外,与不携带 rs2151280 多态等位基因(AA)的患者相比,至少携带一个 rs2151280 多态等位基因(AG + GG)的 DR 患者的肾小球滤过率和高密度脂蛋白胆固醇水平较低,这揭示了 rs2151280 在糖尿病肾脏和心血管并发症中的促进作用:综上所述,我们的研究结果表明 CDKN2B-AS1 基因多态性对 DR 的进展有影响。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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