The application of organoids in cancers associated with pathogenic infections.

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Medicine Pub Date : 2024-07-25 DOI:10.1007/s10238-024-01435-8

Yuyu Zhang, Tao Liu, Wenting He

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Abstract

Cancers associated with pathogen infections are gradually becoming important threats to human health globally, and it is of great significance to study the mechanisms of pathogen carcinogenesis. Current mechanistic studies rely on animal and two-dimensional (2D) cell culture models, but traditional methods have been proven insufficient for the rapid modeling of diseases caused by new pathogens. Therefore, research focus has shifted to organoid models, which can replicate the structural and genetic characteristics of the target tissues or organs in vitro, providing new platforms for the study of pathogen-induced oncogenic mechanisms. This review summarizes the application of organoid technology in the studies of four pathogen-associated cancers: gastric cancer linked to Helicobacter pylori, liver cancer associated with hepatitis B virus or hepatitis C virus, colorectal cancer caused by Escherichia coli, and cervical cancer related to human papillomavirus. This review also proposes several limitations of organoid technology to optimize organoid models and advance the treatment of cancer associated with pathogen infections in the future.

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有机体在与病原体感染有关的癌症中的应用。

与病原体感染相关的癌症正逐渐成为全球人类健康的重要威胁，研究病原体致癌机制具有重要意义。目前的机理研究主要依靠动物和二维（2D）细胞培养模型，但传统方法已被证明不足以快速模拟新病原体引起的疾病。因此，研究重点已转向类器官模型，这种模型可在体外复制目标组织或器官的结构和遗传特征，为研究病原体诱导的致癌机制提供了新的平台。本综述总结了类器官技术在四种病原体相关癌症研究中的应用：与幽门螺杆菌相关的胃癌、与乙型肝炎病毒或丙型肝炎病毒相关的肝癌、由大肠杆菌引起的结直肠癌以及与人类乳头状瘤病毒相关的宫颈癌。这篇综述还提出了类器官技术的几个局限性，以便在未来优化类器官模型，推进与病原体感染相关的癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Medicine 医学-医学：研究与实验

CiteScore

4.80

自引率

2.20%

发文量

159

审稿时长

2.5 months

期刊介绍： Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.