Line-field confocal optical coherence tomography for the differential diagnosis of porokeratosis from clinical mimickers: a preliminary study.

IF 3.7 4区医学 Q1 DERMATOLOGY

Clinical and Experimental Dermatology Pub Date : 2024-11-22 DOI:10.1093/ced/llae285

Linda Tognetti, Simone Cappilli, Francesca Falcinelli, Simone Soglia, Francesco Lacarrubba, Vincenzo Maione, Costantino Ricci, Mariano Suppa, Marina Venturini, Elisa Cinotti, Alessandro Di Stefani, Jean Luc Perrot, Pietro Rubegni

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Abstract

Background: Porokeratosis variants are relatively rare and can be clinically misdiagnosed with several common papulokeratotic mimickers. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to explore the skin in vivo up to a depth of 500 µm.

Objectives: To investigate the role of LC-OCT in the diagnosis of many porokeratosis variants in a preliminary study.

Method: In total, 130 LC-OCT images were obtained from 98 patients, 45 affected by a porokeratosis variant (69 images) and 53 with a mimicker condition (61 images).

Results: We found almost perfect interobserver agreement for LC-OCT image interpretation and perfect correspondence with the findings from histological slides. In addition, a series of morphological in vivo and three-dimensional features related to the cornoid lamella were detected by LC-OCT that were not visible from the histology.

Conclusions: This device can be proposed to assist with rapid bedside noninvasive differentiation of porokeratosis variants from their mimickers, possibly sparing incisional biopsy in patients where the diagnosis is uncertain.

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线场共聚焦光学相干断层扫描用于从临床模拟器鉴别诊断角化病：初步研究。

角化病变异型相对罕见，临床上可能会被几种常见的丘疹角化病模拟器误诊。线场共聚焦光学相干断层扫描（LC-OCT）是一种新技术，能够在体内探索深度达 500 微米的皮肤。在这项初步研究中，我们旨在探讨 LC-OCT 在诊断多种角化病变异中的作用。我们对 54 名患者（28 人患有 13 种角化病变异中的一种，26 人患有模拟病症）进行了垂直和水平视角的病变和周围部位检查。我们发现，LC-OCT 图像的判读与组织学切片完全一致，观察者之间几乎完全一致。此外，LC-OCT 还检测到一系列与矢状膜相关的活体形态和三维特征，而这些特征在组织学中是看不到的。该设备可用于在床边快速无创区分角化病变体和模拟变体，从而避免对可疑病例进行切口活检。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

2.40%

发文量

389

审稿时长

3-8 weeks

期刊介绍： Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.