Association Between Handgrip Strength and Mortality of Patients With Coronary Artery Disease: A Meta-Analysis

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Cardiology Pub Date : 2024-07-25 DOI:10.1002/clc.24322

Meiling Xiao, Yu Lu, Hongqiu Li, Zhonghai Zhao

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引用次数: 0

Abstract

Background

Muscular strength has been linked to increased risk of cardiovascular disease in the community population. The aim of this systematic review and meta-analysis is to evaluate the association between weak handgrip strength (HGS) and mortality risk in patients with coronary artery disease (CAD).

Methods

To carry out the meta-analysis, an extensive search was conducted on databases such as PubMed, Embase, Web of Science, Cochrane Library, Wanfang, and CNKI to identify observational studies with longitudinal follow-up. Random-effects models were used to combine the findings, taking into account the potential influence of heterogeneity.

Results

Eight observational studies involving 10 543 patients with CAD were included. During a mean follow-up duration of 20.4 months, 1327 (12.6%) patients died. Pooled results showed that weak HGS at baseline was associated with an increased risk of all-cause mortality during follow-up (risk ratio [RR]: 1.95, 95% confidence interval: 1.50 to 2.55, p < 0.001; I² = 62%). Subgroup analysis suggested a stronger association between weak HGS and increased mortality in older patients with CAD as compared to that of overall adult patients with CAD (RR: 3.01 vs. 1.60, p for subgroup difference = 0.004). Subgroup analyses according to study location, design, subtype of CAD, follow-up duration, analytical model, and study quality scores showed similar results (p for subgroup difference all > 0.05).

Conclusions

Weak HGS at baseline is associated with an increased risk of mortality in patients with CAD, particularly in older patients with CAD.

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手握强度与冠心病患者死亡率之间的关系：一项 Meta 分析

背景：在社区人群中，肌肉力量与心血管疾病风险的增加有关。本系统综述和荟萃分析旨在评估弱握力（HGS）与冠状动脉疾病（CAD）患者死亡风险之间的关联：为了进行荟萃分析，我们在 PubMed、Embase、Web of Science、Cochrane Library、Wanfang 和 CNKI 等数据库中进行了广泛搜索，以确定具有纵向随访的观察性研究。考虑到异质性的潜在影响，采用随机效应模型对研究结果进行综合分析：结果：共纳入了 8 项观察性研究，涉及 10 543 名 CAD 患者。在平均 20.4 个月的随访期间，有 1327 名（12.6%）患者死亡。汇总结果显示，基线HGS较弱与随访期间全因死亡风险增加有关（风险比[RR]：1.95，95% 置信区间：1.50 至 2.55，P 2 = 62%）。亚组分析表明，与所有成人 CAD 患者相比，老年 CAD 患者的弱 HGS 与死亡率增加之间的关系更为密切（RR：3.01 vs. 1.60，亚组差异 p = 0.004）。根据研究地点、设计、CAD 亚型、随访时间、分析模型和研究质量评分进行的亚组分析显示了相似的结果（亚组差异 p 均大于 0.05）：结论：基线HGS较弱与CAD患者死亡风险增加有关，尤其是老年CAD患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cardiology 医学-心血管系统

CiteScore

5.10

自引率

3.70%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.