A Short Progressive Supranuclear Palsy Quality of Life Scale

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-07-26 DOI:10.1002/mds.29936

Ida Jensen MD, Stephanie Stiel PhD, Sarah Bebermeier PhD, Anette Schrag MD, Stephan Greten MD, Johanna Doll-Lee MD, Florian Wegner MD, Lan Ye MD, Johanne Heine MD, Lea Krey MD, Matthias Höllerhage MD, Patrick Süß MD, Jürgen Winkler MD, Daniela Berg MD, Steffen Paschen MD, Lars Tönges MD, Doreen Gruber MD, Florin Gandor MD, Wolfgang H. Jost MD, Andrea A. Kühn MD, Inga Claus MD, Tobias Warnecke MD, David J. Pedrosa MD, Carsten Eggers MD, Claudia Trenkwalder MD, Joseph Classen MD, Johannes Schwarz MD, Monika Pötter-Nerger MD, Jan Kassubek MD, Alfons Schnitzler MD, Günter U. Höglinger MD, Martin Klietz MD

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引用次数: 0

Abstract

Objective

The Progressive Supranuclear Palsy quality of life scale (PSP-QoL) has been shown to be a useful tool for capturing health-related quality of life of patients in “everyday life” and in progressive supranuclear palsy (PSP) research. However, at 45 items in length, the questionnaire can take a long time, exhausting PSP patients, in particular if cognitive impaired, which can have a negative impact on the assessment. The aim of this study was to establish a condensed version of the PSP-QoL for research and routine clinical care.

Methods

In this retrospective study, data originating from a German cohort of PSP patients was analyzed. Data from 245 PSP patients were included in this study. The short PSP-QoL questionnaire was created using a two-factor solution and item-total and inter-item correlations for mental and physical aspects of daily living of the PSP-QoL followed by confirmatory factor analysis.

Results

The final scale included 12 items representing mental (five items) and physical symptoms (seven items). The specified two-factor model displayed an excellent fit in the confirmatory factor analysis. The short Progressive Supranuclear Palsy Quality of Life scale (PSP-ShoQoL) correlated moderately with the PSP Rating Scale (r [243] = 0.514, P < 0.001) and Geriatric depression scale (r [231] = 0.548, P < 0.001). Sensitivity to change confirmed a significant decrease in QoL after 12 months.

Discussion

In this study, we created a 12-item PSP-ShoQoL designed to “facilitate” daily clinical work that correlated strongly with the PSP-QoL and was sensitive to change. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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渐进性核上性麻痹生活质量简表

目的：进行性核上性麻痹生活质量量表（PSP-QoL）已被证明是在 "日常生活 "和进行性核上性麻痹（PSP）研究中获取患者健康相关生活质量的有效工具。然而，该问卷长达 45 个条目，可能会耗费很长时间，使 PSP 患者疲惫不堪，尤其是在认知能力受损的情况下，这可能会对评估产生负面影响。本研究的目的是为研究和常规临床护理建立一个浓缩版的 PSP-QoL：在这项回顾性研究中，我们分析了来自德国一组 PSP 患者的数据。本研究纳入了 245 名 PSP 患者的数据。在对 PSP-QoL进行确认性因子分析后，采用双因子解法、PSP-QoL中日常生活的精神和身体方面的项目总相关性和项目间相关性，编制了简短的PSP-QoL问卷：最终量表包括 12 个项目，分别代表精神症状（5 个项目）和躯体症状（7 个项目）。在确认性因子分析中，指定的双因子模型显示出了极佳的拟合度。简短的进行性核上麻痹生活质量量表（PSP-ShoQoL）与 PSP 评定量表呈中度相关（r [243] = 0.514，P 讨论）：在这项研究中，我们设计了一个由12个项目组成的PSP-ShoQoL，旨在 "促进 "日常临床工作，该量表与PSP-QoL有很强的相关性，并且对变化很敏感。© 2024 作者。运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.