Sex similarities and divergences in systemic and muscle iron metabolism adaptations to extreme physical inactivity in rats

IF 8.9 1区医学

Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2024-07-24 DOI:10.1002/jcsm.13547

Mathieu Horeau, Melissa Delalande, Martine Ropert, Patricia Leroyer, Brice Martin, Luz Orfila, Olivier Loréal, Frédéric Derbré

引用次数: 0

Abstract

Previous data in humans suggest that extreme physical inactivity (EPI) affects iron metabolism differently between sexes. Our objective was to deepen the underlying mechanisms by studying rats of both sexes exposed to hindlimb unloading (HU), the reference experimental model mimicking EPI.

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大鼠全身和肌肉铁代谢对极端缺乏运动的适应性的性别相似性和差异性

以前的人类数据表明，极端缺乏体力活动（EPI）对铁代谢的影响在性别上有所不同。我们的目的是通过研究暴露于后肢卸载（HU）（模拟 EPI 的参考实验模型）的雌雄大鼠来深入研究其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine

自引率

12.40%

发文量

期刊介绍： The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.

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