Causal Relationship Between Obstructive Sleep Apnea and Temporomandibular Disorders: A Bidirectional Mendelian Randomization Analysis

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-07-23 DOI:10.2147/nss.s476277

Yu-Pei Wang, Hui-Xia Wei, Yuan-Yuan Hu, Yu-Ming Niu

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引用次数: 0

Abstract

Objective: This study was conducted to investigate the bidirectional causal relationship between obstructive sleep apnea (OSA) and temporomandibular disorders (TMD).
Methods: Using an online pooled dataset of genome-wide association studies (GWAS), a two-sample bi-directional Mendelian randomization (MR) method was implemented. Inverse variance weighting was used as the primary analyses approach, and other methods of MR Egger, weighted median method, MR-Egger, Simple mode, and Weighted mode analysis were conducted as supplements to evaluate the causal relationship between OSA and TMD with odds ratios (OR) and 95% confidence interval (CI). Furthermore, the Cochran Q, MR-Egger, and MR-PRESSO approaches were used to perform the heterogeneity test and multiple validity.
Results: The general results of the forward MR analysis indicated that OSA had a significant causal influence on TMD (OR=1.241, 95% CI: 1.009– 1.526, P=0.041), but no significant correlation was observed in the reverse MR analysis (IVW: OR=0.975, 95% CI=0.918– 1.036, P=0.411).
Conclusion: In summary, our research demonstrated a hereditary causative relationship between OSA and TMD, indicating that appropriate intervention is required for both prevention and treatment of TMD.

Keywords: Mendelian randomization analysis, obstructive sleep apnea, temporomandibular disorders

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阻塞性睡眠呼吸暂停与颞下颌关节紊乱之间的因果关系：双向孟德尔随机分析

研究目的本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）与颞下颌关节紊乱（TMD）之间的双向因果关系：利用全基因组关联研究（GWAS）的在线汇总数据集，采用双样本双向孟德尔随机化（MR）方法。以反向方差加权法作为主要分析方法，并采用 MR Egger、加权中位数法、MR-Egger、简单模式和加权模式分析等其他方法作为补充，通过几率比（OR）和 95% 置信区间（CI）评估 OSA 与 TMD 之间的因果关系。此外，还使用 Cochran Q、MR-Egger 和 MR-PRESSO 方法进行了异质性检验和多重有效性检验：正向 MR 分析的总体结果表明，OSA 对 TMD 有显著的因果影响（OR=1.241，95% CI：1.009- 1.526，P=0.041），但反向 MR 分析未观察到显著的相关性（IVW：OR=0.975，95% CI=0.918- 1.036，P=0.411）：总之，我们的研究证明了 OSA 与 TMD 之间的遗传致病关系，表明需要对 TMD 的预防和治疗进行适当的干预：孟德尔随机分析阻塞性睡眠呼吸暂停颞下颌关节紊乱

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.