A Simple Conversion of Aldoximes to Nitriles Using Thiourea Dioxide

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2024-07-22 DOI:10.1002/ajoc.202400291

Peidong Song, Zhe Cui, Tingting Meng, Haojie Rong, Mingzhen Mao, Cuifeng Yang

引用次数: 0

Abstract

Thiourea dioxide (TDO) has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, alkenyl and aliphatic aldoximes to respective nitriles in excellent yields. Furthermore, this method has been applied to the synthesis of fungicide cyazofamid from a commercial precursor using TDO as a pivotal dehydrating and reducing reagent. This new procedure offers simple and easily reproducible technique for nitrile synthesis and highlights the synthetic utility of TDO as a versatile reagent in organic chemistry.

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利用二氧化硫脲实现醛肟与腈的简单转化

二氧化硫脲（TDO）已被证明是一种高效的试剂，可将芳香族、杂芳香族、烯基和脂肪族醛肟转化为各自的腈，且收率极高。此外，该方法还被应用于以 TDO 作为关键的脱水和还原试剂，从商用前体合成杀菌剂氰霜唑。这一新方法为腈类合成提供了简单且易于重复的技术，并凸显了 TDO 作为有机化学多功能试剂的合成用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.