Application of a calcium and phosphorus biomineralization strategy in tooth repair: a systematic review

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2024-07-12 DOI:10.1039/D4TB00867G

Haide Dong, Danyang Wang, Hanyue Deng, Lijuan Yin, Xiongying Wang, Weihu Yang and Kaiyong Cai

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Abstract

Biomineralization is a natural process in which organisms regulate the growth of inorganic minerals to form biominerals with unique layered structures, such as bones and teeth, primarily composed of calcium and phosphorus. Tooth decay significantly impacts our daily lives, and the key to tooth regeneration lies in restoring teeth through biomimetic approaches, utilizing mineralization strategies or materials that mimic natural processes. This review delves into the types, properties, and transformations of calcium and phosphorus minerals, followed by an exploration of the mechanisms behind physiological and pathological mineralization in living organisms. It summarizes the mechanisms and commonalities of biomineralization and discusses the advancements in dental biomineralization research, guided by insights into calcium and phosphorus mineral biomineralization. This review concludes by addressing the current challenges and future directions in the field of dental biomimetic mineralization.

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钙磷生物矿化策略在牙齿修复中的应用：系统综述。

生物矿化是一个自然过程，生物体通过调节无机矿物质的生长，形成具有独特分层结构的生物矿物质，如主要由钙和磷组成的骨骼和牙齿。蛀牙严重影响着我们的日常生活，而牙齿再生的关键在于通过仿生方法，利用模仿自然过程的矿化策略或材料来修复牙齿。这篇综述深入探讨了钙磷矿物质的类型、特性和转化，随后探讨了生物体内生理和病理矿化背后的机制。综述总结了生物矿化的机制和共性，并以对钙磷矿物生物矿化的见解为指导，讨论了牙科生物矿化研究的进展。本综述最后探讨了牙科生物仿生矿化领域当前的挑战和未来的发展方向。

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices