The impact of herbal treatments on cervicovaginal human papillomavirus infection: a systematic review and meta-analysis.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2024-07-19 eCollection Date: 2024-01-01 DOI:10.1590/1806-9282.20240141

Nuran Gençtürk, Aysu Yildiz Karaahmet, Dilan Cömert

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Abstract

Objective: This systematic review and meta-analysis aimed to investigate the effects of herbal treatments on cervicovaginal human papillomavirus infection.

Methods: A comprehensive literature search was conducted in PubMed, Scopus, Science Direct, and the Cochrane Library until December 2023, following Cochrane guidelines. Data were analyzed using the Review Manager computer program (Version 5.4.1).

Results: Five randomized controlled trials involving a total sample size of 662 women were included in the study. The pooled odds ratio for individuals testing negative for human papillomavirus after herbal intervention among human papillomavirus-positive patients was 1.86 (95% confidence interval (CI) 0.64-5.43), according to the fixed-effects model. Three out of the five studies indicated a significant relationship. The relationship between positive human papillomavirus infection and herbal treatments, measured by the fixed-effects model, resulted in a pooled odds ratio of 0.41 (95%CI 0.17-1.01), reporting a significant association (p=0.05). Subgroup analysis revealed a significant reduction in the relationship between herbal treatment and atypical squamous cells of undetermined significance (OR 0.16, 95%CI 0.03-0.88, p=0.04) but no significant impact on the relationship between herbal treatment and low-grade squamous intraepithelial lesion (OR 0.33, 95%CI 0.01-8.77, p=0.51).

Conclusion: The meta-analysis suggests that herbal treatments reduce human papillomavirus infections. While herbal treatments show a significant reduction in atypical squamous cells of undetermined significance, they do not significantly impact the regression of low-grade squamous intraepithelial lesions.

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草药治疗对宫颈阴道人类乳头瘤病毒感染的影响：系统综述和荟萃分析。

目的本系统综述和荟萃分析旨在研究草药治疗对宫颈阴道人类乳头瘤病毒感染的影响：方法：根据 Cochrane 指南，在 PubMed、Scopus、Science Direct 和 Cochrane 图书馆进行了全面的文献检索，直至 2023 年 12 月。使用 Review Manager 计算机程序（5.4.1 版）对数据进行分析：研究共纳入了五项随机对照试验，涉及样本量共计 662 名女性。根据固定效应模型，在人乳头瘤病毒阳性患者中，经过草药干预后人乳头瘤病毒检测呈阴性者的汇总几率比为 1.86（95% 置信区间（CI）为 0.64-5.43）。五项研究中有三项表明两者之间存在显著关系。根据固定效应模型，人类乳头瘤病毒感染阳性与草药治疗之间的关系得出的汇总几率比为 0.41（95% 置信区间 0.17-1.01），报告了显著的相关性（P=0.05）。亚组分析显示，中药治疗与非典型鳞状细胞之间的关系显著降低（OR 0.16，95%CI 0.03-0.88，p=0.04），但对中药治疗与低级别鳞状上皮内病变之间的关系无显著影响（OR 0.33，95%CI 0.01-8.77，p=0.51）：荟萃分析表明，草药治疗可减少人类乳头瘤病毒感染。虽然草药治疗能显著减少非典型鳞状细胞，但其意义尚不确定，草药治疗对低级别鳞状上皮内病变的消退没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista da Associacao Medica Brasileira (1992)

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